@article{a2390de50f3841a5b6e71879fd906ef5,
title = "Aryloxyacetic esters structurally related to α-Asarone as potential antifungal agents",
abstract = "A series of aryloxyacetic ester analogues 8-13 was synthesized based on the potential pharmacophores of the antifungal agents α-Asarone (1) and 2-5. Their antifungal activity was tested in vitro for their growth inhibitory activities against pathogenic fungi. The in vitro antifungal evaluation of these alkyl and aryl esters shows that derivatives 10 displayed the highest antifungal and fungicidal activities against Cryptococcus neoformans and C. gattii. These results support the idea that the phenoxyacetic frame is a potent pharmacophore for the design of potential antifungal drugs. Graphical Abstract: [Figure not available: see fulltext.]",
keywords = "Antifungal activity, Cryptococcus gattii, Cryptococcus neoformans var. neoformans, Phenoxyacetic frame, α-Asarone",
author = "Fabiola Jim{\'e}nez and Cruz, {Mar{\'i}a Del Carmen} and Clara Z{\'u}{\~n}iga and Mart{\'i}nez, {Mar{\'i}a A.} and Germ{\'a}n Chamorro and Francisco D{\'i}az and Joaqu{\'i}n Tamariz",
note = "Funding Information: Acknowledgments We are grateful to Dr. Cesar H. Hern{\'a}ndez for helpful comments, and Alan Larsen for reviewing the English in the manuscript. F.J., M.C.C., and C.Z. thank CONACYT for awarded scholarships. G.C. is indebted to CONACYT (Grant 38431 N) and to SIP-IPN (970423, 990175, 20060583, and 20070339) for financial support. M.C.Cruz, M.A.M., G.C., F.D., and J.T. are fellows of the EDI/IPN and COFAA/IPN programs.",
year = "2010",
month = feb,
doi = "10.1007/s00044-009-9170-3",
language = "Ingl{\'e}s",
volume = "19",
pages = "33--57",
journal = "Medicinal Chemistry Research",
issn = "1054-2523",
number = "1",
}