TY - JOUR
T1 - Antitumor effect and toxicity of two new active-site-directed irreversible ornithine decarboxylase and extrahepatic arginase inhibitors
AU - Trujillo-Ferrara, José
AU - Koizumi, Guadalupe
AU - Muñnoz, Olga
AU - Joseph-Nathan, Pedro
AU - Yañez, Ricardo
PY - 1992/12/24
Y1 - 1992/12/24
N2 - The irreversible ornithine decarboxylase and extrahepatic arginase inhibitors (+)-S-2-amino-5-iodoacetamidopentanoic acid (2-AIPA) and(+)-S-2-amino-6-iodoacetamido-hexanoic acid (2-AIHA) were evaluated. The LD 50 tests were made in rats and mice using both compounds. Rats and mice were treated with either 2-AIPA or 2-AIHA i.p. for a period of 180 days. The treated animals showed a decrease of total serum proteins and increased ALT and AST levels. CK was also modified but inversely related to dose. Protection tests were carried out using L5178Y mouse lymphosarcoma. The mean survival time for each treated group was calculated and the percentage T C was determined. For 2-AIPA it was 170 and for 2-AIHA it was 210 at 15 mg/kg.
AB - The irreversible ornithine decarboxylase and extrahepatic arginase inhibitors (+)-S-2-amino-5-iodoacetamidopentanoic acid (2-AIPA) and(+)-S-2-amino-6-iodoacetamido-hexanoic acid (2-AIHA) were evaluated. The LD 50 tests were made in rats and mice using both compounds. Rats and mice were treated with either 2-AIPA or 2-AIHA i.p. for a period of 180 days. The treated animals showed a decrease of total serum proteins and increased ALT and AST levels. CK was also modified but inversely related to dose. Protection tests were carried out using L5178Y mouse lymphosarcoma. The mean survival time for each treated group was calculated and the percentage T C was determined. For 2-AIPA it was 170 and for 2-AIHA it was 210 at 15 mg/kg.
KW - (+)-S-2-amino-5-iodoacetamidopentanoic acid
KW - (+)-S-2-amino-6-iodoacetamidohexanoic acid
KW - lymphosarcoma, toxicity, polyamines
UR - http://www.scopus.com/inward/record.url?scp=0027086907&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(92)90143-J
DO - 10.1016/0304-3835(92)90143-J
M3 - Artículo
SN - 0304-3835
VL - 67
SP - 193
EP - 197
JO - Cancer Letters
JF - Cancer Letters
IS - 2-3
ER -