TY - JOUR
T1 - Antimycobacterial activity of Juglans regia, Juglans mollis, Carya illinoensis and Bocconia frutescens
AU - Cruz-Vega, Delia Elva
AU - Verde-Star, María Julia
AU - Salinas-González, Noé
AU - Rosales-Hernández, Bibiana
AU - Estrada-García, Iris
AU - Mendez-Aragón, Patricia
AU - Carranza-Rosales, Pilar
AU - González-Garza, María Teresa
AU - Castro-Garza, Jorge
PY - 2008/4
Y1 - 2008/4
N2 - Mycobacterium tuberculosis is a serious worldwide health threat, killing almost 2 million people per year. Alternative antimycobacterial drugs are urgently needed; studies have shown that medicinal plants traditionally used to treat respiratory diseases are a potential source of compounds to treat tuberculosis. This paper studied the antimycobacterial activity of 28 extracts from four different plant species that have been used in traditional Mexican medicine to treat tuberculosis. Bark and leaf crude extracts of Juglans regia L., Juglans mollis Engelm., Carya illinoensis (Wangenh) K. Koch and Bocconia frutescens showed in vitro anti-M. tuberculosis activity. Hexane bark extracts from C. illinoensis, J. mollis and J. regia were the most active with a minimal inhibitory concentration (MIC) of 31, 50 and 100 μg/mL, respectively. Ethanol bark extracts from C. illinoensis and J. mollis showed activity at 100 and 125 μg/mL, respectively. Leaf extracts had the lowest activity. Methanol and hexane leaves extracts from B. frutescens had a MIC of 125 μg/mL. None of the aqueous extracts showed antimycobacterial activity.
AB - Mycobacterium tuberculosis is a serious worldwide health threat, killing almost 2 million people per year. Alternative antimycobacterial drugs are urgently needed; studies have shown that medicinal plants traditionally used to treat respiratory diseases are a potential source of compounds to treat tuberculosis. This paper studied the antimycobacterial activity of 28 extracts from four different plant species that have been used in traditional Mexican medicine to treat tuberculosis. Bark and leaf crude extracts of Juglans regia L., Juglans mollis Engelm., Carya illinoensis (Wangenh) K. Koch and Bocconia frutescens showed in vitro anti-M. tuberculosis activity. Hexane bark extracts from C. illinoensis, J. mollis and J. regia were the most active with a minimal inhibitory concentration (MIC) of 31, 50 and 100 μg/mL, respectively. Ethanol bark extracts from C. illinoensis and J. mollis showed activity at 100 and 125 μg/mL, respectively. Leaf extracts had the lowest activity. Methanol and hexane leaves extracts from B. frutescens had a MIC of 125 μg/mL. None of the aqueous extracts showed antimycobacterial activity.
KW - Bocconia frutescens
KW - Carya illinoensis
KW - Juglans mollis
KW - Juglans regia
KW - Mycobacterium tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=42949124959&partnerID=8YFLogxK
U2 - 10.1002/ptr.2343
DO - 10.1002/ptr.2343
M3 - Artículo
SN - 0951-418X
VL - 22
SP - 557
EP - 559
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 4
ER -