TY - JOUR
T1 - Antimicrobial activity of pregnenolone-carbamazepine complex on S. Aureus, K. Pneumoniae and E. Coli
AU - Figueroa-Valverde, Lauro
AU - Díaz-Cedillo, Francisco
AU - López-Ramos, María
AU - Garcia-Cervera, Elodia
AU - Torres-Cruz, Rogaciano
AU - Reyna-Moo, Jorge
PY - 2010/9
Y1 - 2010/9
N2 - In this work the antibacterial activity of pregnenolone-carbamazepine complex was evaluated on S. Aureus, K. pneumoniae and E. coli. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of microbial minimal inhibitory. The results indicate that bacterial growth of S. Aureus was inhibited with cefotaxime (MIC=5.23 × 10-4 mmol), gentamicin (MIC=2.68 × 10-5 mmol), ciprofloxacin (MIC=3.77 × 10-4 mmol), hemisuccinate-pregnenolone (MIC=2.40 × 10-3 mmol), carbamazepine-aminocapric acid (MIC=6.80 × 10-4 mmol) and the pregnenolone-carbamazepine complex (MIC=1.39 × 10-4 mmol). Other results showed that bacterial growth of E. coli was inhibited with cefotaxime (MIC=5.23 × 10-4 mmol), gentamicin (MIC=1.34 × 10-5 mmol), ciprofloxacin (MIC=3.01 × 10-3 mmol), hemisuccinate-pregnenolone (MIC=2.40 × 10-3 mmol), carbamazepine-aminocapric acid (MIC=1.36 × 10-3 mmol) and the pregnenolone-carbamazepine complex (MIC=3.18 × 10-4 mmol). Alternative experimental, indicate that bacterial growth of K. pneumoniae was inhibited with cefotaxime (MIC=2.61 × 10-4 mmol), gentamicin (MIC=2.68 × 10-5 mmol), ciprofloxacin (MIC=1.50 × 10-3 mmol), hemisuccinate-pregnenolone (MIC=2.40 × 10-3 mmol), carbamazepine-aminocapric acid (MIC=1.36 × 10-3 mmol) and the pregnenolone-carbamazepine complex (MIC=3.18 × 10-4 mmol). In conclusion, S. Aureus, K. pneumoniae and E. Coli were more susceptible to both gentamicin and pregnenenolone-carbamazepine complex and were more resistant to that hemisuccinate-pregnenenolone conjugate. Possibly the molecular mechanism of pregnenolone-carbamazepine could be by mimic the actions of several steroid-derivates with antibacterial characteristics.
AB - In this work the antibacterial activity of pregnenolone-carbamazepine complex was evaluated on S. Aureus, K. pneumoniae and E. coli. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of microbial minimal inhibitory. The results indicate that bacterial growth of S. Aureus was inhibited with cefotaxime (MIC=5.23 × 10-4 mmol), gentamicin (MIC=2.68 × 10-5 mmol), ciprofloxacin (MIC=3.77 × 10-4 mmol), hemisuccinate-pregnenolone (MIC=2.40 × 10-3 mmol), carbamazepine-aminocapric acid (MIC=6.80 × 10-4 mmol) and the pregnenolone-carbamazepine complex (MIC=1.39 × 10-4 mmol). Other results showed that bacterial growth of E. coli was inhibited with cefotaxime (MIC=5.23 × 10-4 mmol), gentamicin (MIC=1.34 × 10-5 mmol), ciprofloxacin (MIC=3.01 × 10-3 mmol), hemisuccinate-pregnenolone (MIC=2.40 × 10-3 mmol), carbamazepine-aminocapric acid (MIC=1.36 × 10-3 mmol) and the pregnenolone-carbamazepine complex (MIC=3.18 × 10-4 mmol). Alternative experimental, indicate that bacterial growth of K. pneumoniae was inhibited with cefotaxime (MIC=2.61 × 10-4 mmol), gentamicin (MIC=2.68 × 10-5 mmol), ciprofloxacin (MIC=1.50 × 10-3 mmol), hemisuccinate-pregnenolone (MIC=2.40 × 10-3 mmol), carbamazepine-aminocapric acid (MIC=1.36 × 10-3 mmol) and the pregnenolone-carbamazepine complex (MIC=3.18 × 10-4 mmol). In conclusion, S. Aureus, K. pneumoniae and E. Coli were more susceptible to both gentamicin and pregnenenolone-carbamazepine complex and were more resistant to that hemisuccinate-pregnenenolone conjugate. Possibly the molecular mechanism of pregnenolone-carbamazepine could be by mimic the actions of several steroid-derivates with antibacterial characteristics.
KW - Antibacterial activity
KW - Complex
KW - Pregnenolone-carbamazepine
UR - http://www.scopus.com/inward/record.url?scp=79952028465&partnerID=8YFLogxK
M3 - Artículo
SN - 0976-044X
VL - 4
SP - 7
EP - 12
JO - International Journal of Pharmaceutical Sciences Review and Research
JF - International Journal of Pharmaceutical Sciences Review and Research
IS - 1
ER -