TY - JOUR
T1 - Anti-inflammatory activity of aqueous and methanolic extracts of Oenothera rosea Ĺ Hér. ex Ait in the rat
AU - Márquez-Flores, Yazmín K.
AU - Montellano-Rosales, Hortensia
AU - Campos Aldrete, Ma Elena
AU - Meléndez-Camargo, Ma Estela
PY - 2009/7
Y1 - 2009/7
N2 - Oenothera rosea Ĺ Hér. ex Ait. (Onagraceae) is commonly known as hierba del golpe. It is used in Mexican Folk Medicine to treat inflammatory, renal and bacterial diseases. The aim of this study was to evaluate the anti-inflammatory activity of aqueous and methanolic extracts of this plant. Aqueous extract at a dose of 500 mg/kg body weight (b.wt.) and methanolic extract (100 mg/kg b.wt.) of Oenothera rosea were evaluated for anti-inflammatory activity using the cotton pellet-induced granuloma formation model in rat and histological techniques. Both extracts produced a significant decrease of the inflammatory process in relation with the control groups (p<0.05). The anti-inflammatory effect of methanolic extract was similar to the effect of indomethacin. This data was supported by the histological results. No extracts produced gastrointestinal damage. The LD 50 of aqueous and methanol extracts, was higher than 40 and 8 g/kg, respectively. These results suggest that both extracts of Oenothera rosea induced anti-inflammatory activity and it was considered not toxic.
AB - Oenothera rosea Ĺ Hér. ex Ait. (Onagraceae) is commonly known as hierba del golpe. It is used in Mexican Folk Medicine to treat inflammatory, renal and bacterial diseases. The aim of this study was to evaluate the anti-inflammatory activity of aqueous and methanolic extracts of this plant. Aqueous extract at a dose of 500 mg/kg body weight (b.wt.) and methanolic extract (100 mg/kg b.wt.) of Oenothera rosea were evaluated for anti-inflammatory activity using the cotton pellet-induced granuloma formation model in rat and histological techniques. Both extracts produced a significant decrease of the inflammatory process in relation with the control groups (p<0.05). The anti-inflammatory effect of methanolic extract was similar to the effect of indomethacin. This data was supported by the histological results. No extracts produced gastrointestinal damage. The LD 50 of aqueous and methanol extracts, was higher than 40 and 8 g/kg, respectively. These results suggest that both extracts of Oenothera rosea induced anti-inflammatory activity and it was considered not toxic.
KW - Anti-inflammatory
KW - Cotton pellet granuloma
KW - Indomethacin
KW - Oenothera rosea
KW - Onagraceae
UR - http://www.scopus.com/inward/record.url?scp=74549185132&partnerID=8YFLogxK
M3 - Artículo
SN - 1027-3956
VL - 40
SP - 11
EP - 16
JO - Revista Mexicana de Ciencias Farmaceuticas
JF - Revista Mexicana de Ciencias Farmaceuticas
IS - 3
ER -