Anti-epileptic activity, toxicity and teratogenicity in CD1 mice of a novel valproic acid arylamide derivative, N-(2-hydroxyphenyl)-2-propylpentanamide

Medicina y ciencias biológicas

• N-(2-hydroxyphenyl)-2-propylpentanamide 100%
• Valproic Acid 46%
• Electroshock 23%
• Seizures 18%
• Pentylenetetrazole 15%
• Embryonic and Fetal Development 9%
• Rotarod Performance Test 8%
• Stupor 8%
• Lethal Dose 50 6%
• Locomotion 5%
• Anticonvulsants 5%
• Computer Simulation 5%
• Embryonic Development 5%
• Embryonic Structures 4%
• Fetus 4%
• Antioxidants 4%
• Extremities 4%
• Pregnancy 3%
• Cell Line 3%
• Mortality 3%
• Neoplasms 1%

Química

• Arylamide 64%
• Valproic Acid 61%
• Marker 10%
• Convulsion 8%
• Antiproliferative 6%
• Protective 4%
• Antioxidant Agent 4%
• Modification 3%
• Time 2%