TY - JOUR
T1 - Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-α gene in Maya-Mestizo women with preeclampsia
AU - Canto-Cetina, Thelma
AU - Canizales-Quinteros, Samuel
AU - De La Chesnaye, Elsa
AU - Coral-Vázquez, Ramón
AU - Méndez, Juan Pablo
AU - Canto, Patricia
N1 - Funding Information:
This work was supported by Coordinación de Investigación en Salud, Instituto Mexicano del Seguro Social, México, Grant: 2006/1A)/I/033.
PY - 2007/7
Y1 - 2007/7
N2 - Objective: To determine whether polymorphisms in the TNF-α promoter gene are associated with preeclampsia. Methods: 105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed. Results: The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly. Conclusion: We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.
AB - Objective: To determine whether polymorphisms in the TNF-α promoter gene are associated with preeclampsia. Methods: 105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed. Results: The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly. Conclusion: We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.
KW - C-850T polymorphism
KW - G-308A polymorphism
KW - Maya-Mestizo women
KW - Preeclampsia
KW - Promoter of the TNF-α
UR - http://www.scopus.com/inward/record.url?scp=34548069161&partnerID=8YFLogxK
U2 - 10.1080/10641950701372732
DO - 10.1080/10641950701372732
M3 - Artículo
C2 - 17710577
SN - 1064-1955
VL - 26
SP - 283
EP - 291
JO - Hypertension in Pregnancy
JF - Hypertension in Pregnancy
IS - 3
ER -