TY - JOUR
T1 - Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease
AU - Campos-Peña, Victoria
AU - Pichardo-Rojas, Pavel
AU - Sánchez-Barbosa, Talía
AU - Ortíz-Islas, Emma
AU - Rodríguez-Pérez, Citlali Ekaterina
AU - Montes, Pedro
AU - Ramos-Palacios, Gerardo
AU - Silva-Adaya, Daniela
AU - Valencia-Quintana, Rafael
AU - Cerna-Cortes, Jorge Francisco
AU - Toral-Rios, Danira
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs) is one of the main features that define Alzheimer’s disease. Studies have suggested that the accumulation of these peptides in the brain significantly contributes to extensive neuronal loss. Furthermore, the content and distribution of cholesterol in the membrane have been shown to have an important effect on the production and subsequent accumulation of Aβ peptides in the plasma membrane, contributing to dysfunction and neuronal death. The monomeric forms of these membrane-bound peptides undergo several conformational changes, ranging from oligomeric forms to beta-sheet structures, each presenting different levels of toxicity. Aβ peptides can be internalized by particular receptors and trigger changes from Tau phosphorylation to alterations in cognitive function, through dysfunction of the cholinergic system. The goal of this review is to summarize the current knowledge on the role of lipids in Alzheimer’s disease and their relationship with the basal cholinergic system, as well as potential disease-modifying therapies.
AB - The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs) is one of the main features that define Alzheimer’s disease. Studies have suggested that the accumulation of these peptides in the brain significantly contributes to extensive neuronal loss. Furthermore, the content and distribution of cholesterol in the membrane have been shown to have an important effect on the production and subsequent accumulation of Aβ peptides in the plasma membrane, contributing to dysfunction and neuronal death. The monomeric forms of these membrane-bound peptides undergo several conformational changes, ranging from oligomeric forms to beta-sheet structures, each presenting different levels of toxicity. Aβ peptides can be internalized by particular receptors and trigger changes from Tau phosphorylation to alterations in cognitive function, through dysfunction of the cholinergic system. The goal of this review is to summarize the current knowledge on the role of lipids in Alzheimer’s disease and their relationship with the basal cholinergic system, as well as potential disease-modifying therapies.
KW - Alzheimer’s disease
KW - amyloid β
KW - cholesterol
KW - cholinergic system
KW - lipid rafts
UR - http://www.scopus.com/inward/record.url?scp=85140811917&partnerID=8YFLogxK
U2 - 10.3390/ijms232012092
DO - 10.3390/ijms232012092
M3 - Artículo de revisión
C2 - 36292947
AN - SCOPUS:85140811917
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 20
M1 - 12092
ER -