Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun

J. Arrieta; B. Reyes; F. Calzada; R. Cedillo-Rivera; A. Navarrete

doi:10.1016/S0367-326X(00)00297-5

Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun

J. Arrieta, B. Reyes, F. Calzada, R. Cedillo-Rivera, A. Navarrete

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Resumen

The crude ethanol extract from the leaves of Zanthoxylum liebmannianum exhibited inhibitory effect on the reproduction of trophozoites of Entamoeba histolytica (IC₅₀=3.48 μg/ml) and Giardia lamblia (IC₅₀=58.00 μg/ml). From this extract, asarinin, hyperin, β-sitosterol, and β-sitosterol glucoside were isolated. Among them, asarinin was the most active with IC₅₀ values of 19.86 μg/ml for E. histolytica and 35.45 μg/ml for G. lamblia. The remaining compounds showed moderate activity against both parasites.

Idioma original	Inglés
Páginas (desde-hasta)	295-297
Número de páginas	3
Publicación	Fitoterapia
Volumen	72
N.º	3
DOI	https://doi.org/10.1016/S0367-326X(00)00297-5
Estado	Publicada - 2001
Publicado de forma externa	Sí

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@article{6793a820daee431fa6e3858d64671c83,

title = "Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun",

abstract = "The crude ethanol extract from the leaves of Zanthoxylum liebmannianum exhibited inhibitory effect on the reproduction of trophozoites of Entamoeba histolytica (IC50=3.48 μg/ml) and Giardia lamblia (IC50=58.00 μg/ml). From this extract, asarinin, hyperin, β-sitosterol, and β-sitosterol glucoside were isolated. Among them, asarinin was the most active with IC50 values of 19.86 μg/ml for E. histolytica and 35.45 μg/ml for G. lamblia. The remaining compounds showed moderate activity against both parasites.",

keywords = "Antiprotozoal activity, Asarinin, Flavonoids, Sterols, Triterpenoids, Zanthoxylum liebmannianum",

author = "J. Arrieta and B. Reyes and F. Calzada and R. Cedillo-Rivera and A. Navarrete",

note = "Funding Information: Support of this research was provide in part by Direcci{\'o}n General de Asuntos del Personal Acad{\'e}mico (DGAPA) UNAM grant IN 228198.",

year = "2001",

doi = "10.1016/S0367-326X(00)00297-5",

language = "Ingl{\'e}s",

volume = "72",

pages = "295--297",

journal = "Fitoterapia",

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T1 - Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun

AU - Arrieta, J.

AU - Reyes, B.

AU - Calzada, F.

AU - Cedillo-Rivera, R.

AU - Navarrete, A.

N1 - Funding Information: Support of this research was provide in part by Dirección General de Asuntos del Personal Académico (DGAPA) UNAM grant IN 228198.

PY - 2001

Y1 - 2001

N2 - The crude ethanol extract from the leaves of Zanthoxylum liebmannianum exhibited inhibitory effect on the reproduction of trophozoites of Entamoeba histolytica (IC50=3.48 μg/ml) and Giardia lamblia (IC50=58.00 μg/ml). From this extract, asarinin, hyperin, β-sitosterol, and β-sitosterol glucoside were isolated. Among them, asarinin was the most active with IC50 values of 19.86 μg/ml for E. histolytica and 35.45 μg/ml for G. lamblia. The remaining compounds showed moderate activity against both parasites.

AB - The crude ethanol extract from the leaves of Zanthoxylum liebmannianum exhibited inhibitory effect on the reproduction of trophozoites of Entamoeba histolytica (IC50=3.48 μg/ml) and Giardia lamblia (IC50=58.00 μg/ml). From this extract, asarinin, hyperin, β-sitosterol, and β-sitosterol glucoside were isolated. Among them, asarinin was the most active with IC50 values of 19.86 μg/ml for E. histolytica and 35.45 μg/ml for G. lamblia. The remaining compounds showed moderate activity against both parasites.

KW - Antiprotozoal activity

KW - Asarinin

KW - Flavonoids

KW - Sterols

KW - Triterpenoids

KW - Zanthoxylum liebmannianum

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U2 - 10.1016/S0367-326X(00)00297-5

DO - 10.1016/S0367-326X(00)00297-5

M3 - Artículo

SN - 0367-326X

VL - 72

SP - 295

EP - 297

JO - Fitoterapia

JF - Fitoterapia

IS - 3

ER -

Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun

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