TY - JOUR
T1 - Activity induced by dihydrotestosterone-dihydropyrimidine derivative on perfusion pressure and coronary resistance in isolated rat heart
AU - Lauro, Figueroa Valverde
AU - Francisco, Díaz Cedillo
AU - Ma, Lopez Ramos
AU - Elodia, Garcia Cervera
AU - Karen, Quijano A.
PY - 2010/12
Y1 - 2010/12
N2 - Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced by dihydrotestosterone and dihydrotestosterone-dihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity exerted by dihydrotestosterone-derivative was characterized. The results showed that dihydrotestosterone-dihydropyrimidine [10-9 mM] significantly increase the perfusion pressure (p = 0.005) and coronary resistance (p = 0.006) in isolated rat heart. Additionally, the activity exerted by dihydrotestosterone-dihydropyrimidine on perfusion pressure [109 to 10-4 mM] was blocked in the presence of nefidepine [10-6 mM].These data suggest that activity induced by dihydrotestosteronederivative on perfusion pressure and coronary resistance is dependent upon its chemical structure. This phenomenon possibly involves the L-type calcium channel activation through a non-genomic molecular mechanism.
AB - Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced by dihydrotestosterone and dihydrotestosterone-dihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity exerted by dihydrotestosterone-derivative was characterized. The results showed that dihydrotestosterone-dihydropyrimidine [10-9 mM] significantly increase the perfusion pressure (p = 0.005) and coronary resistance (p = 0.006) in isolated rat heart. Additionally, the activity exerted by dihydrotestosterone-dihydropyrimidine on perfusion pressure [109 to 10-4 mM] was blocked in the presence of nefidepine [10-6 mM].These data suggest that activity induced by dihydrotestosteronederivative on perfusion pressure and coronary resistance is dependent upon its chemical structure. This phenomenon possibly involves the L-type calcium channel activation through a non-genomic molecular mechanism.
KW - Dihydrotestosterone
KW - Perfusion pressure
KW - Vascular resistance
UR - http://www.scopus.com/inward/record.url?scp=79951797258&partnerID=8YFLogxK
M3 - Artículo
SN - 1996-0816
VL - 4
SP - 851
EP - 859
JO - African Journal of Pharmacy and Pharmacology
JF - African Journal of Pharmacy and Pharmacology
IS - 12
ER -