Resumen
A new diasteroselective approach for the preparation of chiral α-hydroxy-β-amino acids is described. It is based on the conjugate addition of either (R)-(+)-methylbenzylamine (4) or its lithium salt to the captodative olefins: methyl 2-aroyloxy- and 2-methacryloxy acrylates, 1a-1b and 1c. The highest diastereoselectivity is obtained when the addition is carried out with the chiral lithium amide in the presence of trialkylsilyl chlorides.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 233-249 |
Número de páginas | 17 |
Publicación | Arkivoc |
Volumen | 2005 |
N.º | 6 |
Estado | Publicada - 20 jun. 2005 |