A facile synthesis of an androsterone derivative. QSAR study

In this work our initial design included the synthesis of an androsterone derivative and its relationship with several physicochemical parameters. The first step was achieved by the reacting between montelukast (1) with androsterone (2) to form 3 using 1,3-dicyclohexylcarbodiimide as catalyst. In the second stage, the results showed an increase in the values of of logP, π, R_m, V_m, and P_c in 3 with respect to 1 and 2, nevertheless, S_t was high in 3 in comparison with 2 and similar to 1. These data suggest that physicochemical parameters can affect the degree of lipophilicity of 3 and 5.