TY - JOUR
T1 - A Complete Review of Mexican Plants with Teratogenic Effects
AU - Chamorro-Cevallos, Germán
AU - Mojica-Villegas, María Angélica
AU - García-Martínez, Yuliana
AU - Pérez-Gutiérrez, Salud
AU - Madrigal-Santillán, Eduardo
AU - Vargas-Mendoza, Nancy
AU - Morales-González, José A.
AU - Cristóbal-Luna, José Melesio
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - In Mexico, the use of medicinal plants is the first alternative to treat the diseases of the most economically vulnerable population. Therefore, this review offers a list of Mexican plants (native and introduced) with teratogenic effects and describes their main alterations, teratogenic compounds, and the models and doses used. Our results identified 63 species with teratogenic effects (19 native) and the main alterations that were found in the nervous system and axial skeleton, induced by compounds such as alkaloids, terpenes, and flavonoids. Additionally, a group of hallucinogenic plants rich in alkaloids employed by indigenous groups without teratogenic studies were identified. Our conclusion shows that several of the identified species are employed in Mexican traditional medicine and that the teratogenic species most distributed in Mexico are Astragalus mollissimus, Astragalus lentiginosus, and Lupinus formosus. Considering the total number of plants in Mexico (≈29,000 total vascular plants), to date, existing research in the area shows that Mexican plants with teratogenic effects represent ≈0.22% of the total species of these in the country. This indicates a clear need to intensify the evaluation of the teratogenic effect of Mexican plants.
AB - In Mexico, the use of medicinal plants is the first alternative to treat the diseases of the most economically vulnerable population. Therefore, this review offers a list of Mexican plants (native and introduced) with teratogenic effects and describes their main alterations, teratogenic compounds, and the models and doses used. Our results identified 63 species with teratogenic effects (19 native) and the main alterations that were found in the nervous system and axial skeleton, induced by compounds such as alkaloids, terpenes, and flavonoids. Additionally, a group of hallucinogenic plants rich in alkaloids employed by indigenous groups without teratogenic studies were identified. Our conclusion shows that several of the identified species are employed in Mexican traditional medicine and that the teratogenic species most distributed in Mexico are Astragalus mollissimus, Astragalus lentiginosus, and Lupinus formosus. Considering the total number of plants in Mexico (≈29,000 total vascular plants), to date, existing research in the area shows that Mexican plants with teratogenic effects represent ≈0.22% of the total species of these in the country. This indicates a clear need to intensify the evaluation of the teratogenic effect of Mexican plants.
KW - Mexican plants
KW - alkaloids
KW - pregnancy exposure
KW - teratogenic effects
KW - traditional medicine
UR - http://www.scopus.com/inward/record.url?scp=85134002408&partnerID=8YFLogxK
U2 - 10.3390/plants11131675
DO - 10.3390/plants11131675
M3 - Artículo de revisión
C2 - 35807626
AN - SCOPUS:85134002408
SN - 2223-7747
VL - 11
JO - Plants
JF - Plants
IS - 13
M1 - 1675
ER -