TY - JOUR
T1 - A comparative study of CYP3A4 polymorphisms in Mexican Amerindian and Mestizo populations
AU - Reyes-Hernández, Octavio D.
AU - Lares-Asseff, Ismael
AU - Sosa-Macias, Martha
AU - Vega, Libia
AU - Albores, Arnulfo
AU - Elizondo, Guillermo
PY - 2008/1
Y1 - 2008/1
N2 - Cytochrome P-450 3A4 (CYP3A4) contributes to the metabolism of approximately half the drugs in clinical use today. The aim of the present study was to determine the frequency of the CYP3A4*1B, *2, *4, *5, and *18 alleles amongst both Tepehuan Amerindians, a native group that has inhabited northern Mexico for thousands of years, and Mestizo Mexicans, and to compare the data with those of other populations. Genotyping experiments revealed that 8.8 and 8.0% of the Mestizo and Tepehuano subjects, respectively, carried the CYP3A4*1B allele. Only one Mestizo subject was heterozygous for the CYP3A4*2 variant, while CYP3A4*4, *5 and *18 allelic variants were not detected in either group. On the other hand, the frequencies of the CYP3A4*1B variant in Mestizos and Tepehuanos were similar to those reported for Caucasians, but different from those observed for African and Asian populations.
AB - Cytochrome P-450 3A4 (CYP3A4) contributes to the metabolism of approximately half the drugs in clinical use today. The aim of the present study was to determine the frequency of the CYP3A4*1B, *2, *4, *5, and *18 alleles amongst both Tepehuan Amerindians, a native group that has inhabited northern Mexico for thousands of years, and Mestizo Mexicans, and to compare the data with those of other populations. Genotyping experiments revealed that 8.8 and 8.0% of the Mestizo and Tepehuano subjects, respectively, carried the CYP3A4*1B allele. Only one Mestizo subject was heterozygous for the CYP3A4*2 variant, while CYP3A4*4, *5 and *18 allelic variants were not detected in either group. On the other hand, the frequencies of the CYP3A4*1B variant in Mestizos and Tepehuanos were similar to those reported for Caucasians, but different from those observed for African and Asian populations.
KW - Cytochrome P-450 3A4
KW - Drug-metabolizing enzymes
KW - Genetic polymorphism
UR - http://www.scopus.com/inward/record.url?scp=38749126770&partnerID=8YFLogxK
U2 - 10.1159/000109983
DO - 10.1159/000109983
M3 - Artículo
C2 - 17952011
AN - SCOPUS:38749126770
SN - 0031-7012
VL - 81
SP - 97
EP - 103
JO - Pharmacology
JF - Pharmacology
IS - 2
ER -