TY - JOUR
T1 - 3,5,3'-Triiodothyronine administered to rat dams during lactation increases milk yield and triglyceride concentration and hastens pups growth
AU - Quevedo-Corona, Lucía
AU - Franco-Colín, Margarita
AU - Caudillo-Romero, Mayra
AU - Pacheco-Rosado, Jorge
AU - Zamudio-Hernández, Sergio
AU - Racotta, Radu
N1 - Funding Information:
This work was supported in part by DEPI-IPN grant #901661.L QC, JPR, SZH and RR acknowledget he supporto f DEDICT-COFAA-IPN and MFC the supporto f CONACYT.
PY - 2000/4/14
Y1 - 2000/4/14
N2 - It is known that lactation induces a mild hypothyroid state in rats and other mammals while thyroid hormone administration increases milk secretion in ruminants. The aim of this study was to investigate the effects of a moderate dose of 3,5,3'-triiodothyronine (T3), administered to rat dams during lactation on pups' growth and milk yield and composition. Primiparous Wistar rats with litters adjusted to 10 pups per dam received either tap water or T3 (75 μg/kg·day) in their drinking water from parturition till weaning. Food and water intake of dams and body weight of dams and pups were measured daily. In other groups of rats with similar treatments, milk yield of dams, macronutrient milk composition, and mammary arteriovenous differences for triglycerides (TG) and glucose were also determined. Dams treated with T3 ingested more food and their pups gained more weight than controls. Milk yield, milk TG concentration and glucose extraction by mammary glands were also higher in T3 treated dams. The results show that compensation of the mild hypothyroidism of the lactating rat may contribute to an increase in milk production and lipid levels, leading to an increase in growth of pups.
AB - It is known that lactation induces a mild hypothyroid state in rats and other mammals while thyroid hormone administration increases milk secretion in ruminants. The aim of this study was to investigate the effects of a moderate dose of 3,5,3'-triiodothyronine (T3), administered to rat dams during lactation on pups' growth and milk yield and composition. Primiparous Wistar rats with litters adjusted to 10 pups per dam received either tap water or T3 (75 μg/kg·day) in their drinking water from parturition till weaning. Food and water intake of dams and body weight of dams and pups were measured daily. In other groups of rats with similar treatments, milk yield of dams, macronutrient milk composition, and mammary arteriovenous differences for triglycerides (TG) and glucose were also determined. Dams treated with T3 ingested more food and their pups gained more weight than controls. Milk yield, milk TG concentration and glucose extraction by mammary glands were also higher in T3 treated dams. The results show that compensation of the mild hypothyroidism of the lactating rat may contribute to an increase in milk production and lipid levels, leading to an increase in growth of pups.
KW - Lactation
KW - Milk composition
KW - Milk yield
KW - Pup growth
KW - Rat
KW - Thyroid hormone
UR - http://www.scopus.com/inward/record.url?scp=0034646890&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(00)00528-2
DO - 10.1016/S0024-3205(00)00528-2
M3 - Artículo
SN - 0024-3205
VL - 66
SP - 2013
EP - 2021
JO - Life Sciences
JF - Life Sciences
IS - 21
ER -