Wound healing properties of triterpenes from Buddleia scordioides in diabetic rats

The pentacyclic triterpenes 3-O-α-l-rhamnopyranosyl-(1 → 4)-β -d-glucopyranosyl-(1 → 3)-[β-d-glucopyranosyl-(1 → 2)]-β-d- fucopyranosyl-23,28-dihydroxy-oleane-11, 13(18)-diene (1) and 3-O-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 3)-[β-d-glucopyranosyl-(1 → 2)]-β-d-fucopyranosyl-16,23,28- trihydroxy-oleane-11,13(18)-diene (2) isolated from leaves of Buddleia scordioides Kunth (Loganiaceae) were studied for the effect on wound healing, using excision and incision wound modes. Significant increase in granulation tissue, tensile strength, hydroxyproline, total protein, and collagen contents was observed. There was significant reduction in the wound area measurement of the test group compared with that of controls. The efficacious prohealing effect may be due to increased collagen deposition as well as to better alignment and maturation.