Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads

Icela Palma; Nayely Garibay; Rocio Pena-Yolanda; Alejandra Contreras; Atlantida Raya; Carolina Dominguez; Mirna Romero; Gerardo Aristi; Gloria Queipo

doi:10.3233/DMA-130972

Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads

Icela Palma, Nayely Garibay, Rocio Pena-Yolanda, Alejandra Contreras, Atlantida Raya, Carolina Dominguez, Mirna Romero, Gerardo Aristi, Gloria Queipo

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

BACKGROUND: Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. OBJECTIVE: Determine whether OCT3/4 and β-catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4-β-catenin pathways in the malignant invasive behavior. METHODS: dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma. RESULTS: Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β-catenin does not participate in this process. CONCLUSIONS: The use of this biological markers detects the potential high risk gonads.

Original language	English
Pages (from-to)	419-424
Number of pages	6
Journal	Disease Markers
Volume	34
Issue number	6
DOIs	https://doi.org/10.3233/DMA-130972
State	Published - 2013

Keywords

Gonadoblastoma
OCT3/4
TSPY
dysgenetic gonads
mixed gonadal dysgenesis
β-catenin

Access to Document

10.3233/DMA-130972

Cite this

@article{af6351d8f3764595b298d9e9f1eb1d87,

title = "Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads",

abstract = "BACKGROUND: Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. OBJECTIVE: Determine whether OCT3/4 and β-catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4-β-catenin pathways in the malignant invasive behavior. METHODS: dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma. RESULTS: Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β-catenin does not participate in this process. CONCLUSIONS: The use of this biological markers detects the potential high risk gonads.",

keywords = "Gonadoblastoma, OCT3/4, TSPY, dysgenetic gonads, mixed gonadal dysgenesis, β-catenin",

author = "Icela Palma and Nayely Garibay and Rocio Pena-Yolanda and Alejandra Contreras and Atlantida Raya and Carolina Dominguez and Mirna Romero and Gerardo Aristi and Gloria Queipo",

year = "2013",

doi = "10.3233/DMA-130972",

language = "Ingl{\'e}s",

volume = "34",

pages = "419--424",

journal = "Disease Markers",

issn = "0278-0240",

number = "6",

}

TY - JOUR

T1 - Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads

AU - Palma, Icela

AU - Garibay, Nayely

AU - Pena-Yolanda, Rocio

AU - Contreras, Alejandra

AU - Raya, Atlantida

AU - Dominguez, Carolina

AU - Romero, Mirna

AU - Aristi, Gerardo

AU - Queipo, Gloria

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. OBJECTIVE: Determine whether OCT3/4 and β-catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4-β-catenin pathways in the malignant invasive behavior. METHODS: dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma. RESULTS: Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β-catenin does not participate in this process. CONCLUSIONS: The use of this biological markers detects the potential high risk gonads.

AB - BACKGROUND: Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. OBJECTIVE: Determine whether OCT3/4 and β-catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4-β-catenin pathways in the malignant invasive behavior. METHODS: dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma. RESULTS: Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β-catenin does not participate in this process. CONCLUSIONS: The use of this biological markers detects the potential high risk gonads.

KW - Gonadoblastoma

KW - OCT3/4

KW - TSPY

KW - dysgenetic gonads

KW - mixed gonadal dysgenesis

KW - β-catenin

UR - http://www.scopus.com/inward/record.url?scp=84878836653&partnerID=8YFLogxK

U2 - 10.3233/DMA-130972

DO - 10.3233/DMA-130972

M3 - Artículo

C2 - 23396295

SN - 0278-0240

VL - 34

SP - 419

EP - 424

JO - Disease Markers

JF - Disease Markers

IS - 6

ER -

Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this