Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism

Medicine & Life Sciences

• Agastache 100%
• ursolic acid 73%
• TRPV1 receptor 67%
• Capsaicin 19%
• NG-Nitroarginine Methyl Ester 19%
• Pain Measurement 16%
• Quinoxalines 12%
• Flumazenil 11%
• Soluble Guanylyl Cyclase 10%
• Triterpenes 10%
• Receptor, Serotonin, 5-HT1A 10%
• Phosphodiesterase Inhibitors 10%
• ethyl acetate 9%
• Nociception 9%
• Diclofenac 9%
• Theophylline 9%
• Acetic Acid 9%
• Naloxone 8%
• Traditional Medicine 8%
• Sleep Initiation and Maintenance Disorders 8%
• Methanol 8%
• Nitric Oxide Synthase 8%
• Constriction 8%
• Arginine 7%
• Psychological Inhibition 6%
• Anti-Inflammatory Agents 6%
• Anxiety 5%
• Calcium 5%
• Pain 4%
• Pharmaceutical Preparations 3%

Chemistry

• Antinociceptive 68%
• Ursolic Acid 67%
• Capsaicin 23%
• Intracolonic 17%
• Diclofenac(1-) 16%
• Formaldehyde 14%
• Neurogenic 14%
• Flumazenil 13%
• Naloxone 11%
• L-Arginine 10%
• Theophylline 9%
• Nonsteroid Antiinflammatory Agent 9%
• Triterpene 9%
• Agonist 7%
• Antagonist 7%
• Ethyl Acetate 7%
• Methyl Ester 7%
• Acetic Acid 6%
• Additive 5%
• Methanol 5%
• Reduction 3%