TY - JOUR
T1 - Urinary porphyrins and heme biosynthetic enzyme activities measured by HPLC in arsenic toxicity
AU - García-Vargas, Gonzalo G.
AU - Hernández-Zavala, Araceli
PY - 1996
Y1 - 1996
N2 - Arsenic can modify the urinary excretion of porphyrins in animals and humans. Arsenic also interferes with the activities of several enzymes of the heme biosynthesis pathway, such as aminolevulinate synthase (ALA-S), porphobilinogen deaminase (PBGD), uroporphyrinogen III synthase (Uro III S), uroporphyrinogen decarboxylase (URO-D), coproporphyrinogen oxidase (COPRO-O), ferrochelatase and heme oxygenase (H-O). This review deals with HPLC-based techniques for the analysis of porphyrins in human and rodent urine and several heme enzymes with discussion on their usefulness as early biomarkers of arsenic toxicity.
AB - Arsenic can modify the urinary excretion of porphyrins in animals and humans. Arsenic also interferes with the activities of several enzymes of the heme biosynthesis pathway, such as aminolevulinate synthase (ALA-S), porphobilinogen deaminase (PBGD), uroporphyrinogen III synthase (Uro III S), uroporphyrinogen decarboxylase (URO-D), coproporphyrinogen oxidase (COPRO-O), ferrochelatase and heme oxygenase (H-O). This review deals with HPLC-based techniques for the analysis of porphyrins in human and rodent urine and several heme enzymes with discussion on their usefulness as early biomarkers of arsenic toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0029850590&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-0801(199611)10:6<278::AID-BMC613>3.0.CO;2-X
DO - 10.1002/(SICI)1099-0801(199611)10:6<278::AID-BMC613>3.0.CO;2-X
M3 - Artículo de revisión
SN - 0269-3879
VL - 10
SP - 278
EP - 284
JO - Biomedical Chromatography
JF - Biomedical Chromatography
IS - 6
ER -