TY - JOUR
T1 - Uncatalyzed One-pot diastereoselective synthesis of α-amino phosphonates under solvent-free conditions
AU - Tibhe, Gaurao D.
AU - Lagunas-Rivera, Selene
AU - Vargas-Díaz, Elena
AU - García-Barradas, Oscar
AU - Ordoñez, Mario
PY - 2010/12
Y1 - 2010/12
N2 - Uncatalyzed one-pot, three-component reactions of aldehydes, chiral α-methylamines, and dimethyl phosphite under solvent-free conditions were used for the diastereoselective synthesis of α-amino phosphonates. The reactions proceeded with extremely high efficiency under mild conditions and gave good yields and diastereoselectivities (70:30 to 93:7 dr). This approach could be useful for the large-scale synthesis of several α-amino phosphonates.
AB - Uncatalyzed one-pot, three-component reactions of aldehydes, chiral α-methylamines, and dimethyl phosphite under solvent-free conditions were used for the diastereoselective synthesis of α-amino phosphonates. The reactions proceeded with extremely high efficiency under mild conditions and gave good yields and diastereoselectivities (70:30 to 93:7 dr). This approach could be useful for the large-scale synthesis of several α-amino phosphonates.
KW - Diastereoselectivity
KW - Kabachnik-Fields reaction
KW - Multicomponent reactions
KW - Phosphorus
KW - α-Amino phosphonates
KW - α-Amino phosphonic acids
UR - http://www.scopus.com/inward/record.url?scp=78649571395&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201001096
DO - 10.1002/ejoc.201001096
M3 - Artículo
AN - SCOPUS:78649571395
SN - 1434-193X
SP - 6573
EP - 6581
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 34
ER -