TY - JOUR
T1 - Trypanothione reductase
T2 - A target for the development of anti-Trypanosoma cruzi drugs
AU - Vázquez, Karina
AU - Paulino, Margot
AU - Salas, Cristian O.
AU - Zarate-Ramos, Juan J.
AU - Vera, Brenda
AU - Rivera, Gildardo
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017
Y1 - 2017
N2 - Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi. Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
AB - Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi. Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
KW - Chagas disease
KW - Drugs
KW - Inhibitors
KW - Target
KW - Trypanosoma cruzi
KW - Trypanothione reductase
UR - http://www.scopus.com/inward/record.url?scp=85025144785&partnerID=8YFLogxK
U2 - 10.2174/1389557517666170315145410
DO - 10.2174/1389557517666170315145410
M3 - Artículo de revisión
C2 - 28302040
SN - 1389-5575
VL - 17
SP - 939
EP - 946
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 11
ER -