TY - JOUR
T1 - Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi
AU - Nogueda-Torres, B.
AU - Rodríguez-Páez, L.
AU - Ramírez, I. B.
AU - Ramírez, C. W.
PY - 2001
Y1 - 2001
N2 - We synthesized and study the possible trypanocidal activity of 4-isopropyl salicylaldehyde and 4-isopropyl salicylic acid, these compounds were chemical derivatives of gossypol, a drug that inhibits the growth of T. cruzi in culture. These derivatives were tested in two T. cruzi strains with different in vitro susceptibility to benznidazole and nifurtimox, used as a reference drugs. It was found that they were better inhibitors of T. cruzi α-hydroxyacid dehydrogenase than gossypol, in both strains. The in vitro and in vivo pharmacological tests were performed and in both test, the gossypol derivatives showed a higher and better trypanocidal effect than gossypol, and a higher and much better trypanocidal effect than nifurtimox and benznidazole in the two studied T. cruzi strains. The trypanocidal effect was higher in the NINOA strain than in the MIGUZ strain.
AB - We synthesized and study the possible trypanocidal activity of 4-isopropyl salicylaldehyde and 4-isopropyl salicylic acid, these compounds were chemical derivatives of gossypol, a drug that inhibits the growth of T. cruzi in culture. These derivatives were tested in two T. cruzi strains with different in vitro susceptibility to benznidazole and nifurtimox, used as a reference drugs. It was found that they were better inhibitors of T. cruzi α-hydroxyacid dehydrogenase than gossypol, in both strains. The in vitro and in vivo pharmacological tests were performed and in both test, the gossypol derivatives showed a higher and better trypanocidal effect than gossypol, and a higher and much better trypanocidal effect than nifurtimox and benznidazole in the two studied T. cruzi strains. The trypanocidal effect was higher in the NINOA strain than in the MIGUZ strain.
KW - 4-Isopropyl salicylaldehyde
KW - 4-Isopropyl salicylic acid
KW - Trypanocidal drugs
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=0034876644&partnerID=8YFLogxK
M3 - Artículo
SN - 0187-4640
VL - 43
SP - 1
EP - 6
JO - Revista latinoamericana de microbiologia
JF - Revista latinoamericana de microbiologia
IS - 1
ER -