Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis

Anahí C. Sánchez-Chávez, Anuar Salazar-Gómez, L. Gerardo Zepeda-Vallejo, María de L. Hernández de Jesús, Manuel Quintos-Escalante, Ma Elena Vargas-Díaz, Julieta Luna-Herrera

Research output: Contribution to journalArticle

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Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group A phytochemical and antibacterial study of Trixis angustifolia, a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against Mycobacterium tuberculosis H37Rv was 25 μg/mL. The hexanic extract caused a significant inhibition of intracellular mycobacterial growth at 12.5 μg/mL. The biodirected assay of hexane extract enabled the detection of an active fraction (AF) against M. tuberculosis (MIC = 12.5 μg/mL), and a major flavone 1 (pebrellin) with no antimycobacterial activity (MIC > 200 μg/mL). A subsequent combination antimicrobial assay showed a synergistic antimycobacterial effect of AF in combination with pebrellin; the results of the synergistic activity suggest that the antimycobacterial activity found in T. angustifolia is due to the combined action of diverse metabolites present in the plant.
Original languageAmerican English
Pages (from-to)1-5
Number of pages0
JournalNatural Product Research
DOIs
StatePublished - 24 Dec 2017

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Asteraceae
flavone
Mycobacterium tuberculosis
tuberculosis
Assays
Tuberculosis
flavones
Flavones
extracts
Phytochemicals
Hexanes
Metabolites
Mexico
assays
hexane
phytopharmaceuticals
indigenous species
Growth
anti-infective agents
metabolites

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Sánchez-Chávez, Anahí C. ; Salazar-Gómez, Anuar ; Zepeda-Vallejo, L. Gerardo ; Hernández de Jesús, María de L. ; Quintos-Escalante, Manuel ; Vargas-Díaz, Ma Elena ; Luna-Herrera, Julieta. / Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis. In: Natural Product Research. 2017 ; pp. 1-5.
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Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis. / Sánchez-Chávez, Anahí C.; Salazar-Gómez, Anuar; Zepeda-Vallejo, L. Gerardo; Hernández de Jesús, María de L.; Quintos-Escalante, Manuel; Vargas-Díaz, Ma Elena; Luna-Herrera, Julieta.

In: Natural Product Research, 24.12.2017, p. 1-5.

Research output: Contribution to journalArticle

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AU - Hernández de Jesús, María de L.

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N2 - © 2017 Informa UK Limited, trading as Taylor & Francis Group A phytochemical and antibacterial study of Trixis angustifolia, a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against Mycobacterium tuberculosis H37Rv was 25 μg/mL. The hexanic extract caused a significant inhibition of intracellular mycobacterial growth at 12.5 μg/mL. The biodirected assay of hexane extract enabled the detection of an active fraction (AF) against M. tuberculosis (MIC = 12.5 μg/mL), and a major flavone 1 (pebrellin) with no antimycobacterial activity (MIC > 200 μg/mL). A subsequent combination antimicrobial assay showed a synergistic antimycobacterial effect of AF in combination with pebrellin; the results of the synergistic activity suggest that the antimycobacterial activity found in T. angustifolia is due to the combined action of diverse metabolites present in the plant.

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Sánchez-Chávez AC, Salazar-Gómez A, Zepeda-Vallejo LG, Hernández de Jesús MDL, Quintos-Escalante M, Vargas-Díaz ME et al. Trixis angustifolia hexanic extract displays synergistic antibacterial activity against M. tuberculosis. Natural Product Research. 2017 Dec 24;1-5. https://doi.org/10.1080/14786419.2017.1416381