TY - JOUR
T1 - TREM-1 modulation during early stages of dengue virus infection
AU - Ruiz-Pacheco, J. A.
AU - Vivanco-Cid, H.
AU - Izaguirre-Hernández, I. Y.
AU - Estrada-García, I.
AU - Arriaga-Pizano, L.
AU - Chacón-Salinas, R.
AU - Fonseca-Coronado, S.
AU - Vaughan, G.
AU - Ruiz Tovar, K.
AU - Rivera-Osorio, M. P.
AU - Escobar-Gutiérrez, A.
N1 - Funding Information:
This research was partly supported by the Fondo Sectorial de Investigación en Salud y Seguridad Social SSA/IMSS/ISSSTE-CONACyT (Registers 139542 and 161716) and the Fondo Sectorial de Investigación SEP-CONACyT, Ciencia Basica Project (Register 157274).
PY - 2014/3
Y1 - 2014/3
N2 - Uncontrolled and intricate production of inflammatory factors is the characteristic feature of dengue infection. The triggering receptor expressed in myeloid cells-1 (TREM-1), expressed on the surface of monocytes and neutrophils, is capable of enhancing and regulating the inflammatory response via the production of different mediators in bacterial and viral infections. Here, both the expression of TREM-1 on human monocytes and neutrophils from peripheral blood of dengue infected individuals, as well as the levels of the soluble form of TREM-1 (sTREM-1) in the sera of these patients were compared against healthy controls. A significant reduction of TREM-1 expression was observed in neutrophils during the first days of infection, followed by a gradual recovery throughout the course of infection. Also, sera from DENV-infected patients exhibited significantly higher sTREM-1 levels than healthy individuals. The difference was more pronounced during the first 5 days after the onset of symptoms. These findings highlight the dynamic process of TREM-1 expression during DENV infection. We hypothesized that increment of free sTREM-1 could be a compensatory mechanism aiming to counteract the inflammatory process elicited during DENV infection.
AB - Uncontrolled and intricate production of inflammatory factors is the characteristic feature of dengue infection. The triggering receptor expressed in myeloid cells-1 (TREM-1), expressed on the surface of monocytes and neutrophils, is capable of enhancing and regulating the inflammatory response via the production of different mediators in bacterial and viral infections. Here, both the expression of TREM-1 on human monocytes and neutrophils from peripheral blood of dengue infected individuals, as well as the levels of the soluble form of TREM-1 (sTREM-1) in the sera of these patients were compared against healthy controls. A significant reduction of TREM-1 expression was observed in neutrophils during the first days of infection, followed by a gradual recovery throughout the course of infection. Also, sera from DENV-infected patients exhibited significantly higher sTREM-1 levels than healthy individuals. The difference was more pronounced during the first 5 days after the onset of symptoms. These findings highlight the dynamic process of TREM-1 expression during DENV infection. We hypothesized that increment of free sTREM-1 could be a compensatory mechanism aiming to counteract the inflammatory process elicited during DENV infection.
KW - Dengue virus
KW - Innate immunity
KW - STREM-1
KW - TREM-1
UR - http://www.scopus.com/inward/record.url?scp=84893484564&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2014.01.003
DO - 10.1016/j.imlet.2014.01.003
M3 - Artículo
C2 - 24447863
SN - 0165-2478
VL - 158
SP - 183
EP - 188
JO - Immunology Letters
JF - Immunology Letters
IS - 1-2
ER -