Transformación oxidativa del esteroide 19-noretindrona en mestranol

Héctor Salgado-Zamora; G. Emigdia Flores; A. Ma Elena Campos; J. Rogelio Jiménez

Transformación oxidativa del esteroide 19-noretindrona en mestranol

Translated title of the contribution: Oxidative transformation of steroid 19-norethindrone into mestranol

Héctor Salgado-Zamora, G. Emigdia Flores, A. Ma Elena Campos, J. Rogelio Jiménez

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The development of an alternative procedure for the oxidation of steroid 19-norethindrone (an androgen) into semi-synthetic steroid mestranol (an estrogen) is described. The study evaluated the use of alkylorthoformiates in the A-ring steroid aromatization process. It was found that methyl orthoformate does catalize the ethindrone oxidation process, thus improving mestranol isolation yield. The methodology here described results in a convenient mestranol laboratory scale preparation.

Translated title of the contribution	Oxidative transformation of steroid 19-norethindrone into mestranol
Original language	Spanish
Pages (from-to)	32-36
Number of pages	5
Journal	Revista Mexicana de Ciencias Farmaceuticas
Volume	33
Issue number	4
State	Published - Oct 2002

Cite this

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title = "Transformaci{\'o}n oxidativa del esteroide 19-noretindrona en mestranol",

abstract = "The development of an alternative procedure for the oxidation of steroid 19-norethindrone (an androgen) into semi-synthetic steroid mestranol (an estrogen) is described. The study evaluated the use of alkylorthoformiates in the A-ring steroid aromatization process. It was found that methyl orthoformate does catalize the ethindrone oxidation process, thus improving mestranol isolation yield. The methodology here described results in a convenient mestranol laboratory scale preparation.",

keywords = "19-norethindrone, Mestranol, Oxidation, Steroids",

author = "H{\'e}ctor Salgado-Zamora and Flores, {G. Emigdia} and Campos, {A. Ma Elena} and Jim{\'e}nez, {J. Rogelio}",

year = "2002",

month = oct,

language = "Espa{\~n}ol",

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journal = "Revista Mexicana de Ciencias Farmaceuticas",

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TY - JOUR

T1 - Transformación oxidativa del esteroide 19-noretindrona en mestranol

AU - Salgado-Zamora, Héctor

AU - Flores, G. Emigdia

AU - Campos, A. Ma Elena

AU - Jiménez, J. Rogelio

PY - 2002/10

Y1 - 2002/10

N2 - The development of an alternative procedure for the oxidation of steroid 19-norethindrone (an androgen) into semi-synthetic steroid mestranol (an estrogen) is described. The study evaluated the use of alkylorthoformiates in the A-ring steroid aromatization process. It was found that methyl orthoformate does catalize the ethindrone oxidation process, thus improving mestranol isolation yield. The methodology here described results in a convenient mestranol laboratory scale preparation.

AB - The development of an alternative procedure for the oxidation of steroid 19-norethindrone (an androgen) into semi-synthetic steroid mestranol (an estrogen) is described. The study evaluated the use of alkylorthoformiates in the A-ring steroid aromatization process. It was found that methyl orthoformate does catalize the ethindrone oxidation process, thus improving mestranol isolation yield. The methodology here described results in a convenient mestranol laboratory scale preparation.

KW - 19-norethindrone

KW - Mestranol

KW - Oxidation

KW - Steroids

UR - http://www.scopus.com/inward/record.url?scp=0036816954&partnerID=8YFLogxK

M3 - Artículo

SN - 1027-3956

VL - 33

SP - 32

EP - 36

JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

IS - 4

ER -

Transformación oxidativa del esteroide 19-noretindrona en mestranol

Abstract

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