TY - JOUR
T1 - Transfer factor and allergy
AU - Gómez Vera, Javier
AU - Chávez Sánchez, Raúl
AU - Flores Sandoval, Graciela
AU - Orea Solano, Modesto
AU - López Tiro, José Jesús
AU - Santiago Santos, A. D.
AU - Espinosa Padilla, Sara
AU - Espinosa Rosales, Francisco
AU - Huerta, J.
AU - Ortega Martell, José Antonio
AU - Berrón Pérez, Renato
AU - Estrada García, Alejandro
AU - Pérez Tapia, Mayra
AU - Rodríguez Flores, Azucena
AU - Serrano Miranda, Ernestina
AU - Pineda García, Oscar
AU - Andaluz, Consuelo
AU - Cervantes Trujano, Edgar
AU - Portugués Díaz, Abraham
AU - Barrientos Zamudio, Javier
AU - Cano Ortíz, Laura
AU - Serafín López, Jeanet
AU - Jiménez Martínez, María Del C.armen
AU - Aguilar Velázquez, Gustavo
AU - Garfias Becerra, Yonathan
AU - Santacruz Valdéz, Concepción
AU - Aguilar Ángeles, Daniel
AU - Rojo Guiérrez, María Isabel
AU - Aguilar Santelises, Miguel
AU - Estrada Parra, Sergio
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Although various mechanisms involving antibodies and various cell types participate, a Thl and Th2 cells imbalance seems to play a central role for allergy development. Other lymphocyte subpopulations, such as Th17, CD4 FOXP3, and Th9 positive regulatory T lymphocytes may also be involved in the allergic response. Regulatory processes are an appealing target for therapeutic approaches aiming to solve allergic reactions by restoring the delicate balance within the immune system. Transfer factor (TF) or dialyzable leukocyte extract is meant to transfer cell-mediated immunity from immune competent donors to unsensitized or deficient recipients. A PubMed search on the current knowledge on TF indicates that TF may restore the Th1/Th2 balance and improve immune regulatory mechanisms of patients receiving it. Our preliminary results demonstrate that TF induces mRNA expression of IFN-g, osteopontin, RANTES, and hBD-2 in human healthy subjects. TF has been used to treat a variety of immune dysfunction related-pathologies, such as allergy, autoimmunity, immunodeficiencies, infectious diseases and tumors. Patients receiving TF together with their conventional treatment often have better clinical evolution than without it, as we have witnessed, adding TF to the usual medical treatment of allergic diseases as an attempt to provide allergic patients with those regulatory elements that they apparently lack but require to achieve properly regulated immune responses and thus obtain a faster and better resolution of allergic reactions.
AB - Although various mechanisms involving antibodies and various cell types participate, a Thl and Th2 cells imbalance seems to play a central role for allergy development. Other lymphocyte subpopulations, such as Th17, CD4 FOXP3, and Th9 positive regulatory T lymphocytes may also be involved in the allergic response. Regulatory processes are an appealing target for therapeutic approaches aiming to solve allergic reactions by restoring the delicate balance within the immune system. Transfer factor (TF) or dialyzable leukocyte extract is meant to transfer cell-mediated immunity from immune competent donors to unsensitized or deficient recipients. A PubMed search on the current knowledge on TF indicates that TF may restore the Th1/Th2 balance and improve immune regulatory mechanisms of patients receiving it. Our preliminary results demonstrate that TF induces mRNA expression of IFN-g, osteopontin, RANTES, and hBD-2 in human healthy subjects. TF has been used to treat a variety of immune dysfunction related-pathologies, such as allergy, autoimmunity, immunodeficiencies, infectious diseases and tumors. Patients receiving TF together with their conventional treatment often have better clinical evolution than without it, as we have witnessed, adding TF to the usual medical treatment of allergic diseases as an attempt to provide allergic patients with those regulatory elements that they apparently lack but require to achieve properly regulated immune responses and thus obtain a faster and better resolution of allergic reactions.
UR - http://www.scopus.com/inward/record.url?scp=84979819260&partnerID=8YFLogxK
M3 - Artículo
SN - 0002-5151
VL - 57
SP - 208
EP - 214
JO - Revista Alergia Mexico
JF - Revista Alergia Mexico
IS - 6
ER -