Toxicidad y efecto hipotensor de oxoborolidinona de L-arginina y su modulación por azul de metileno. Comparación con L-arginina, nitrite y nitrate

M. E. Bravo Ávila; J. M. Araujo Álvarez; A. Bustamante Quezada; J. G. Trujillo Ferrara

Toxicidad y efecto hipotensor de oxoborolidinona de L-arginina y su modulación por azul de metileno. Comparación con L-arginina, nitrite y nitrate

Translated title of the contribution: Toxicity and hypotensor effect of oxoborolidinona of L-arginine and its modulation by methylene blue as compared to L-arginine

M. E. Bravo Ávila, J. M. Araujo Álvarez, A. Bustamante Quezada, J. G. Trujillo Ferrara

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Nitric oxide is synthesized by constitutive oxide nitric synthase from the guanidine group of L-arginine. L-arginine, oxoborolidinone of L-arginine, nitrite and nitrate showed dose-dependent hypotensive effects after injection via the femoral vein in Wistar rats. The hypotensive effects were shifted to the right after treatment with methylene blue, which is a synthetic phenothiazine inhibitor of guanylate cyclase. Oxoborolidinone of L-arginine had high hypotensive effects with an effective half dose of 10 ηmoles kg^-1 and of μmoles kg^-1 for methylene blue. Methylene blue also attenuated the toxic effects of all the tested compounds.

Translated title of the contribution	Toxicity and hypotensor effect of oxoborolidinona of L-arginine and its modulation by methylene blue as compared to L-arginine
Original language	Spanish
Pages (from-to)	193-198
Number of pages	6
Journal	Archivos de Cardiologia de Mexico
Volume	71
Issue number	3
State	Published - 2001

Cite this

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title = "Toxicidad y efecto hipotensor de oxoborolidinona de L-arginina y su modulaci{\'o}n por azul de metileno. Comparaci{\'o}n con L-arginina, nitrite y nitrate",

abstract = "Nitric oxide is synthesized by constitutive oxide nitric synthase from the guanidine group of L-arginine. L-arginine, oxoborolidinone of L-arginine, nitrite and nitrate showed dose-dependent hypotensive effects after injection via the femoral vein in Wistar rats. The hypotensive effects were shifted to the right after treatment with methylene blue, which is a synthetic phenothiazine inhibitor of guanylate cyclase. Oxoborolidinone of L-arginine had high hypotensive effects with an effective half dose of 10 ηmoles kg-1 and of μmoles kg-1 for methylene blue. Methylene blue also attenuated the toxic effects of all the tested compounds.",

keywords = "Nitric oxide, Nitric oxide synthase, Oxoborolidinone of L-arginine",

author = "{Bravo {\'A}vila}, {M. E.} and {Araujo {\'A}lvarez}, {J. M.} and {Bustamante Quezada}, A. and {Trujillo Ferrara}, {J. G.}",

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T1 - Toxicidad y efecto hipotensor de oxoborolidinona de L-arginina y su modulación por azul de metileno. Comparación con L-arginina, nitrite y nitrate

AU - Bravo Ávila, M. E.

AU - Araujo Álvarez, J. M.

AU - Bustamante Quezada, A.

AU - Trujillo Ferrara, J. G.

PY - 2001

Y1 - 2001

N2 - Nitric oxide is synthesized by constitutive oxide nitric synthase from the guanidine group of L-arginine. L-arginine, oxoborolidinone of L-arginine, nitrite and nitrate showed dose-dependent hypotensive effects after injection via the femoral vein in Wistar rats. The hypotensive effects were shifted to the right after treatment with methylene blue, which is a synthetic phenothiazine inhibitor of guanylate cyclase. Oxoborolidinone of L-arginine had high hypotensive effects with an effective half dose of 10 ηmoles kg-1 and of μmoles kg-1 for methylene blue. Methylene blue also attenuated the toxic effects of all the tested compounds.

AB - Nitric oxide is synthesized by constitutive oxide nitric synthase from the guanidine group of L-arginine. L-arginine, oxoborolidinone of L-arginine, nitrite and nitrate showed dose-dependent hypotensive effects after injection via the femoral vein in Wistar rats. The hypotensive effects were shifted to the right after treatment with methylene blue, which is a synthetic phenothiazine inhibitor of guanylate cyclase. Oxoborolidinone of L-arginine had high hypotensive effects with an effective half dose of 10 ηmoles kg-1 and of μmoles kg-1 for methylene blue. Methylene blue also attenuated the toxic effects of all the tested compounds.

KW - Nitric oxide

KW - Nitric oxide synthase

KW - Oxoborolidinone of L-arginine

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M3 - Artículo

SN - 1405-9940

VL - 71

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EP - 198

JO - Archivos de Cardiologia de Mexico

JF - Archivos de Cardiologia de Mexico

IS - 3

ER -

Toxicidad y efecto hipotensor de oxoborolidinona de L-arginina y su modulación por azul de metileno. Comparación con L-arginina, nitrite y nitrate

Abstract

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