Abstract
A new glibenclamide-estradiol conjugate was synthesized by the reaction of glibenclamide-succinate and estradiol-ethylenediamine derivative using N,N'-diciclohexylcarbodiimide/p-toluensulfonic acid as catalysts. In order to evaluate the degree of lipophilicity and its relationship with some physicochemical descriptors involved in its chemical structure, the ACD log P and KOWWIN methods were used. The results showed an increase in the values of these physicochemical parameters for the glibenclamide-estradiol conjugate in comparison with glibenclamide and glibenclamide-succinate. These data suggest a relationship between the evaluated physicochemical parameters and the degree of lipophilicity of the glibenclamide-estradiol conjugate.
Original language | English |
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Pages (from-to) | 1405-1409 |
Number of pages | 5 |
Journal | Asian Journal of Chemistry |
Volume | 25 |
Issue number | 3 |
State | Published - 2013 |
Keywords
- Estradiol
- Glibenclamide
- Lipophilicity