TY - JOUR
T1 - The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells
AU - Torres-Flores, Jesús M.
AU - Silva-Ayala, Daniela
AU - Espinoza, Marco A.
AU - López, Susana
AU - Arias, Carlos F.
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2015/1/5
Y1 - 2015/1/5
N2 - Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor.
AB - Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor.
KW - JAM-A
KW - Occludin
KW - Rotavirus
KW - Tight junction proteins
KW - Virus entry
KW - ZO-1
UR - http://www.scopus.com/inward/record.url?scp=84913553760&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2014.11.016
DO - 10.1016/j.virol.2014.11.016
M3 - Artículo
SN - 0042-6822
VL - 475
SP - 172
EP - 178
JO - Virology
JF - Virology
ER -