TY - JOUR
T1 - The Role of Propolis as a Natural Product with Potential Gastric Cancer Treatment Properties
T2 - A Systematic Review
AU - Rivera-Yañez, Nelly
AU - Ruiz-Hurtado, Porfirio Alonso
AU - Rivera-Yañez, Claudia Rebeca
AU - Arciniega-Martínez, Ivonne Maciel
AU - Yepez-Ortega, Mariazell
AU - Mendoza-Arroyo, Belén
AU - Rebollar-Ruíz, Xóchitl Abril
AU - Méndez-Cruz, Adolfo René
AU - Reséndiz-Albor, Aldo Arturo
AU - Nieto-Yañez, Oscar
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Gastric cancer is one of the most common, aggressive, and invasive types of malignant neoplasia. It ranks fifth for incidence and fourth for prevalence worldwide. Products of natural origin, such as propolis, have been assessed for use as new complementary therapies to combat cancer. Propolis is a bee product with antiproliferative and anticancer properties. The concentrations and types of secondary metabolites contained in propolis mainly vary according to the geographical region, the season of the year, and the species of bees that make it. The present study is a systematic review of the main articles related to the effects of propolis against gastric cancer published between 2011 and 2021 in the PubMed and Science Direct databases. Of 1305 articles published, only eight studies were selected; among their principal characteristics was the use of in vitro analysis with cell lines from gastric adenocarcinoma and in vivo murine models of the application of propolis treatments. These studies suggest that propolis arrests the cell cycle and inhibits proliferation, prevents the release of oxidizing agents, and promotes apoptosis. In vivo assays showed that propolis decreased the number of tumors by regulating the cell cycle and the expression of proteins related to apoptosis.
AB - Gastric cancer is one of the most common, aggressive, and invasive types of malignant neoplasia. It ranks fifth for incidence and fourth for prevalence worldwide. Products of natural origin, such as propolis, have been assessed for use as new complementary therapies to combat cancer. Propolis is a bee product with antiproliferative and anticancer properties. The concentrations and types of secondary metabolites contained in propolis mainly vary according to the geographical region, the season of the year, and the species of bees that make it. The present study is a systematic review of the main articles related to the effects of propolis against gastric cancer published between 2011 and 2021 in the PubMed and Science Direct databases. Of 1305 articles published, only eight studies were selected; among their principal characteristics was the use of in vitro analysis with cell lines from gastric adenocarcinoma and in vivo murine models of the application of propolis treatments. These studies suggest that propolis arrests the cell cycle and inhibits proliferation, prevents the release of oxidizing agents, and promotes apoptosis. In vivo assays showed that propolis decreased the number of tumors by regulating the cell cycle and the expression of proteins related to apoptosis.
KW - KATO III
KW - bioactive compounds
KW - cytotoxic effect
KW - gastric cancer
KW - in vivo and in vitro models
KW - propolis
UR - http://www.scopus.com/inward/record.url?scp=85146784757&partnerID=8YFLogxK
U2 - 10.3390/foods12020415
DO - 10.3390/foods12020415
M3 - Artículo de revisión
C2 - 36673507
AN - SCOPUS:85146784757
SN - 2304-8158
VL - 12
JO - Foods
JF - Foods
IS - 2
M1 - 415
ER -
