TY - JOUR
T1 - The pathogen Mycobacterium marinum, a faster growing close relative of Mycobacterium tuberculosis, has a single rRNA operon per genome
AU - Helguera-Repetto, Cecilia
AU - Cox, Robert A.
AU - Muñoz-Sànchez, José L.
AU - Gonzalez-Y-Merchand, Jorge A.
N1 - Funding Information:
We thank Simon A. Cox for his help in the preparation of the manuscript. This work is supported as part of the European Comission Science Research and Development Programme, Contract ICA4-CT-2002-10063. J.A.G-y-M received support from COFAA, EDI and CGPI-20030776, IPN, Mexico, and CONACyT (Grant 37814-N). A.C.H-R received a fellowiship from CONACyT, Mexico.
PY - 2004/6/15
Y1 - 2004/6/15
N2 - Although Mycobacterium marinum and Mycobacterium tuberculosis are very closely related they differ significantly in their growth rates. The Type strain of M. marinum and one clinical isolate were investigated and, like M. tuberculosis, were found to have a single rRNA (rrn) operon per genome located downstream from murA gene and controlled by two promoters. No sequence differences were found that account for the difference in the growth rates of the two species. We infer that M. tuberculosis has the capacity to synthesize rRNA much faster than it actually does; and propose that the high number of insertion sequences in this species attenuate growth rate to lower values.
AB - Although Mycobacterium marinum and Mycobacterium tuberculosis are very closely related they differ significantly in their growth rates. The Type strain of M. marinum and one clinical isolate were investigated and, like M. tuberculosis, were found to have a single rRNA (rrn) operon per genome located downstream from murA gene and controlled by two promoters. No sequence differences were found that account for the difference in the growth rates of the two species. We infer that M. tuberculosis has the capacity to synthesize rRNA much faster than it actually does; and propose that the high number of insertion sequences in this species attenuate growth rate to lower values.
KW - Mycobacterium marinum
KW - Transcription start point
KW - rRNA operon
UR - http://www.scopus.com/inward/record.url?scp=2942621923&partnerID=8YFLogxK
U2 - 10.1016/j.femsle.2004.04.046
DO - 10.1016/j.femsle.2004.04.046
M3 - Artículo
C2 - 15183875
SN - 0378-1097
VL - 235
SP - 281
EP - 288
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2
ER -