The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction

Placido Rojas-Franco, Erick Garcia-Pliego, Alma Gricelda Vite-Aquino, Margarita Franco-Colin, Jose Ivan Serrano-Contreras, Norma Paniagua-Castro, Carlos Angel Gallardo-Casas, Vanessa Blas-Valdivia, Edgar Cano-Europa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

C-phycocyanin (CPC) is an antihypertensive that is not still wholly pharmacologically described. The aim of this study was to evaluate whether CPC counteracts endothelial dysfunction as an antihypertensive mechanism in rats with 5/6 nephrectomy (NFx) as a chronic kidney disease (CKD) model. Twenty-four male Wistar rats were divided into four groups: sham control, sham-treated with CPC (100 mg/Kg/d), NFx, and NFx treated with CPC. Blood pressure was measured each week, and renal function evaluated at the end of the treatment. Afterward, animals were euthanized, and their thoracic aortas were analyzed for endothelium functional test, oxidative stress, and NO production. 5/6 Nephrectomy caused hypertension increasing lipid peroxidation and ROS production, overexpression of inducible nitric oxide synthase (iNOS), reduction in the first-line antioxidant enzymes activities, and reduced-glutathione (GSH) with a down-expression of eNOS. The vasomotor response reduced endothelium-dependent vasodilation in aorta segments exposed to acetylcholine and sodium nitroprusside. However, the treatment with CPC prevented hypertension by reducing oxidative stress, NO system disturbance, and endothelial dysfunction. The CPC treatment did not prevent CKD-caused disturbance in the antioxidant enzymes activities. Therefore, CPC exhibited an antihypertensive activity while avoiding endothelial dysfunction.

Original languageEnglish
Article number1464
JournalNutrients
Volume14
Issue number7
DOIs
StatePublished - 1 Apr 2022

Keywords

  • C-phycocyanin
  • antihy-pertensive
  • chronic kidney disease
  • endothelial dysfunction
  • nephrectomy

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