TY - JOUR
T1 - The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas
AU - García-Ortiz, Humberto
AU - Barajas-Olmos, Francisco
AU - Contreras-Cubas, Cecilia
AU - Cid-Soto, Miguel Ángel
AU - Córdova, Emilio J.
AU - Centeno-Cruz, Federico
AU - Mendoza-Caamal, Elvia
AU - Cicerón-Arellano, Isabel
AU - Flores-Huacuja, Marlen
AU - Baca, Paulina
AU - Bolnick, Deborah A.
AU - Snow, Meradeth
AU - Flores-Martínez, Silvia Esperanza
AU - Ortiz-Lopez, Rocio
AU - Reynolds, Austin W.
AU - Blanchet, Antonio
AU - Morales-Marín, Mirna
AU - Velázquez-Cruz, Rafael
AU - Kostic, Aleksandar David
AU - Galaviz-Hernández, Carlos
AU - García-Zapién, Alejandra Guadalupe
AU - Jiménez-López, José Concepción
AU - León-Reyes, Guadalupe
AU - Salas-Bautista, Eva Gabriela
AU - Lazalde-Ramos, Blanca Patricia
AU - Jiménez-Ruíz, Juan Luis
AU - Salas-Martínez, Guadalupe
AU - Ramos-Madrigal, Jazmín
AU - Mirzaeicheshmeh, Elaheh
AU - Saldaña-Alvarez, Yolanda
AU - del Carmen Abrahantes-Pérez, María
AU - Loeza-Becerra, Francisco
AU - Mojica-Espinosa, Raúl
AU - Sánchez-Quinto, Federico
AU - Rangel-Villalobos, Héctor
AU - Sosa-Macías, Martha
AU - Sánchez-Corona, José
AU - Rojas-Martinez, Augusto
AU - Martínez-Hernández, Angélica
AU - Orozco, Lorena
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15–30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4–9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far.
AB - The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15–30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4–9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far.
UR - http://www.scopus.com/inward/record.url?scp=85117232577&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-26188-w
DO - 10.1038/s41467-021-26188-w
M3 - Artículo
C2 - 34642312
AN - SCOPUS:85117232577
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5942
ER -