TY - JOUR
T1 - The FTO gene is associated with adulthood obesity in the Mexican population
AU - Villalobos-Comparán, Marisela
AU - Teresa Flores-Dorantes, M.
AU - Teresa Villarreal-Molina, M.
AU - Rodríguez-Cruz, Maricela
AU - García-Ulloa, Ana C.
AU - Robles, Lorena
AU - Huertas-Vázquez, Adriana
AU - Saucedo-Villarreal, Nubia
AU - López-Alarcón, Mardia
AU - Sánchez-Muñoz, Fausto
AU - Domínguez-López, Aarón
AU - Gutiérrez-Aguilar, Ruth
AU - Menjivar, Marta
AU - Coral-Vázquez, Ramón
AU - Hernández-Stengele, Gabriel
AU - Vital-Reyes, Victor S.
AU - Acuña-Alonzo, Victor
AU - Romero-Hidalgo, Sandra
AU - Ruiz-Gómez, Doris G.
AU - Riaño-Barros, Daniela
AU - Herrera, Miguel F.
AU - Gómez-Pérez, Francisco J.
AU - Froguel, Philippe
AU - García-García, Eduardo
AU - Teresa Tusié-Luna, M.
AU - Aguilar-Salinas, Carlos A.
AU - Canizales-Quinteros, Samuel
PY - 2008/10
Y1 - 2008/10
N2 - Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican-Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single-nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models (P = 0.0000004 and 0.000008, respectively). These associations remained significant after adjusting for admixture (P = 0.000003 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B-cell function (HOMA-B), and with higher homeostasis model assessment of insulin sensitivity (HOMA-S) only in nonobese individuals (Pdom = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese individuals than in lean individuals (P = 0.043). Risk alleles were significantly associated with higher FTO expression in the class III obesity group (P = 0.047). In conclusion, FTO is a major risk factor for obesity (particularly class III) in the Mexican-Mestizo population, and is upregulated in subcutaneous fat tissue of obese individuals.
AB - Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican-Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single-nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models (P = 0.0000004 and 0.000008, respectively). These associations remained significant after adjusting for admixture (P = 0.000003 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B-cell function (HOMA-B), and with higher homeostasis model assessment of insulin sensitivity (HOMA-S) only in nonobese individuals (Pdom = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese individuals than in lean individuals (P = 0.043). Risk alleles were significantly associated with higher FTO expression in the class III obesity group (P = 0.047). In conclusion, FTO is a major risk factor for obesity (particularly class III) in the Mexican-Mestizo population, and is upregulated in subcutaneous fat tissue of obese individuals.
UR - http://www.scopus.com/inward/record.url?scp=53849111547&partnerID=8YFLogxK
U2 - 10.1038/oby.2008.367
DO - 10.1038/oby.2008.367
M3 - Artículo
C2 - 18719664
SN - 1930-7381
VL - 16
SP - 2296
EP - 2301
JO - Obesity
JF - Obesity
IS - 10
ER -