TY - JOUR
T1 - The evaluation of liver dysfunction and oxidative stress due to urban environmental pollution in Mexican population related to Madin Dam, State of Mexico
T2 - a pilot study
AU - Ruiz-Lara, Karina
AU - García-Medina, Sandra
AU - Galar-Martínez, Marcela
AU - Parra-Ortega, Israel
AU - Morales-Balcázar, Israel
AU - Hernández-Rosas, Nancy Aline
AU - Moreno-Vázquez, Sergio Esteban
AU - Hernández-Díaz, Misael
AU - Cano-Viveros, Selene
AU - Olvera-Roldán, Eduardo Osel
AU - Gómez-Oliván, Leobardo Manuel
AU - Gasca-Pérez, Eloy
AU - García-Medina, Alba Lucero
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/1
Y1 - 2023/1
N2 - One of the most important causes of disease and premature death in the world is environmental pollution. The presence of pollutants in both water and air contributes to the deterioration of the health of human populations. The Mexico City Metropolitan Area is one of the most populous and affected by air pollution worldwide; in addition, in recent years there has been a growing demand for water, so urban reservoirs such as the Madin dam are vital to meet the demand. However, this reservoir is highly polluted due to the urban settlements around it. Therefore, the aim of the present study was to evaluate oxidative stress in clinically healthy subjects by means of the degree of lipoperoxidation, as well as the modification of serum enzyme levels, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase associated with air and drinking water pollutants from three zones of the Mexico City Metropolitan Area, two of them related to Madin Dam. This descriptive cross-sectional study was conducted between March 2019 and September 2021 in 142 healthy participants (age range 18–65 years). Healthy subjects were confirmed by their medical history. The results showed that chronic exposure to air (SO2) and water pollutants (Al and Fe) was significantly associated with elevated levels of lipoperoxidation. There was evidence that contamination from the Madín dam can generate oxidative stress and affect the health status of people who receive water from this reservoir or who consume fish that inhabit it.
AB - One of the most important causes of disease and premature death in the world is environmental pollution. The presence of pollutants in both water and air contributes to the deterioration of the health of human populations. The Mexico City Metropolitan Area is one of the most populous and affected by air pollution worldwide; in addition, in recent years there has been a growing demand for water, so urban reservoirs such as the Madin dam are vital to meet the demand. However, this reservoir is highly polluted due to the urban settlements around it. Therefore, the aim of the present study was to evaluate oxidative stress in clinically healthy subjects by means of the degree of lipoperoxidation, as well as the modification of serum enzyme levels, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase associated with air and drinking water pollutants from three zones of the Mexico City Metropolitan Area, two of them related to Madin Dam. This descriptive cross-sectional study was conducted between March 2019 and September 2021 in 142 healthy participants (age range 18–65 years). Healthy subjects were confirmed by their medical history. The results showed that chronic exposure to air (SO2) and water pollutants (Al and Fe) was significantly associated with elevated levels of lipoperoxidation. There was evidence that contamination from the Madín dam can generate oxidative stress and affect the health status of people who receive water from this reservoir or who consume fish that inhabit it.
KW - Air pollution
KW - Human health effects
KW - Lipoperoxidation
KW - Liver enzymes
KW - Metals
KW - Water pollution
UR - http://www.scopus.com/inward/record.url?scp=85138011186&partnerID=8YFLogxK
U2 - 10.1007/s11356-022-22724-3
DO - 10.1007/s11356-022-22724-3
M3 - Artículo
C2 - 36018407
AN - SCOPUS:85138011186
SN - 0944-1344
VL - 30
SP - 6950
EP - 6964
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
IS - 3
ER -