TY - JOUR
T1 - The efficacy of adipokines and indices of metabolic syndrome as predictors of severe obesity-related hepatic steatosis
AU - Méndez-Sánchez, Nahum
AU - Chávez-Tapia, Norberto C.
AU - Medina-Santillán, Roberto
AU - Villa, Antonio R.
AU - Sánchez-Lara, Karla
AU - Ponciano-Rodríguez, Guadalupe
AU - Ramos, Martha H.
AU - Uribe, Misael
PY - 2006/10
Y1 - 2006/10
N2 - The aim of this study was to investigate adiponectin, leptin, and metabolic syndrome as predictors of the severity of obesity-related steatosis. By ultrasonography steatosis-positive (cases) subjects (n=141) were compared with controls (n=111). Demographic and anthropometric data and serum concentrations of adiponectin, leptin, and insulin were measured. The impact of several criteria of metabolic syndrome, serum adiponectin concentrations, and serum leptin concentrations were tested using a multivariate logistic regression analysis. The frequency of metabolic syndrome was higher in cases (44.0% versus 9.2%; P < .0001). Cases were older and had higher insulin resistance, waist circumference, and lower concentrations of adiponectin (all P < .001). The upper adiponectin quartile was associated with a lesser grade of steatosis. Metabolic syndrome and adiponectin concentrations were independently associated with the probability of steatosis. In conclusion, adipokines and metabolic syndrome are useful indices for the prediction of the severity of obesity-related steatosis.
AB - The aim of this study was to investigate adiponectin, leptin, and metabolic syndrome as predictors of the severity of obesity-related steatosis. By ultrasonography steatosis-positive (cases) subjects (n=141) were compared with controls (n=111). Demographic and anthropometric data and serum concentrations of adiponectin, leptin, and insulin were measured. The impact of several criteria of metabolic syndrome, serum adiponectin concentrations, and serum leptin concentrations were tested using a multivariate logistic regression analysis. The frequency of metabolic syndrome was higher in cases (44.0% versus 9.2%; P < .0001). Cases were older and had higher insulin resistance, waist circumference, and lower concentrations of adiponectin (all P < .001). The upper adiponectin quartile was associated with a lesser grade of steatosis. Metabolic syndrome and adiponectin concentrations were independently associated with the probability of steatosis. In conclusion, adipokines and metabolic syndrome are useful indices for the prediction of the severity of obesity-related steatosis.
KW - Adiponectin
KW - Fatty liver
KW - Hepatic steatosis
KW - Leptin
KW - Liver
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=33749613841&partnerID=8YFLogxK
U2 - 10.1007/s10620-006-9093-5
DO - 10.1007/s10620-006-9093-5
M3 - Artículo
SN - 0163-2116
VL - 51
SP - 1716
EP - 1722
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 10
ER -