TY - JOUR
T1 - The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population
T2 - Association with obesity and obesity-related comorbidities
AU - Villarreal-Molina, M. Teresa
AU - Aguilar-Salinas, Carlos A.
AU - Rodríguez-Cruz, Maricela
AU - Riaño, Daniela
AU - Villalobos-Comparan, Marisela
AU - Coral-Vazquez, Ramon
AU - Menjivar, Marta
AU - Yescas-Gomez, Petra
AU - Königsoerg-Fainstein, Mina
AU - Romero-Hidalgo, Sandra
AU - Tusie-Luna, M. Teresa
AU - Canizales-Quinteros, Samuel
AU - Flores-Dorantes, M. Teresa
AU - Guerra-Garcia, M. Teresa
AU - Huertas-Vazquez, Adriana
AU - Rosales-Escamilla, Alma
AU - Cruz-Bautista, Ivette
AU - Gomez-Perez, Francisco
AU - Ortiz-Lopez, Guadalupe
AU - Brito-Zurita, Olga
AU - Noguchi, Hideyo
AU - Cetina, Thelma Canto De
PY - 2007/7
Y1 - 2007/7
N2 - Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions. Because hypoalphalipoproteinemia is highly prevalent in Mexico, we screened the ABCA1 coding sequence in Mexican individuals with low and high HDL cholesterol levels to seek functional variants. A highly frequent nonsynonymous variant (R230C) was identified in low-HDL cholesterol but not in high-HDL cholesterol individuals (P = 0.00006). We thus assessed its frequency in the Mexican-Mestizo general population, seeking possible associations with several metabolic traits. R230C was screened in 429 Mexican Mestizos using Taqman assays, and it was found in 20.1% of these individuals. The variant was significantly associated not only with decreased HDL cholesterol and apolipoprotein A-I levels but also with obesity (odds ratio 2.527, P = 0.005), the metabolic syndrome (1.893, P = 0.0007), and type 2 diabetes (4.527, P = 0.003). All of these associations remained significant after adjusting for admixture (P = 0.011, P = 0.001, and P = 0.006, respectively). This is the first study reporting the association of an ABCA1 variant with obesity and obesity-related comorbidities as being epidemiologically relevant in the Mexican population.
AB - Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions. Because hypoalphalipoproteinemia is highly prevalent in Mexico, we screened the ABCA1 coding sequence in Mexican individuals with low and high HDL cholesterol levels to seek functional variants. A highly frequent nonsynonymous variant (R230C) was identified in low-HDL cholesterol but not in high-HDL cholesterol individuals (P = 0.00006). We thus assessed its frequency in the Mexican-Mestizo general population, seeking possible associations with several metabolic traits. R230C was screened in 429 Mexican Mestizos using Taqman assays, and it was found in 20.1% of these individuals. The variant was significantly associated not only with decreased HDL cholesterol and apolipoprotein A-I levels but also with obesity (odds ratio 2.527, P = 0.005), the metabolic syndrome (1.893, P = 0.0007), and type 2 diabetes (4.527, P = 0.003). All of these associations remained significant after adjusting for admixture (P = 0.011, P = 0.001, and P = 0.006, respectively). This is the first study reporting the association of an ABCA1 variant with obesity and obesity-related comorbidities as being epidemiologically relevant in the Mexican population.
UR - http://www.scopus.com/inward/record.url?scp=34347382714&partnerID=8YFLogxK
U2 - 10.2337/db06-0905
DO - 10.2337/db06-0905
M3 - Artículo
C2 - 17287470
SN - 0012-1797
VL - 56
SP - 1881
EP - 1887
JO - Diabetes
JF - Diabetes
IS - 7
ER -