TY - JOUR
T1 - The anti-inflammatory properties of halloysite
AU - Cornejo-Garrido, Hilda
AU - Nieto-Camacho, Antonio
AU - Gómez-Vidales, Virginia
AU - Ramírez-Apan, María Teresa
AU - del Angel, Paz
AU - Montoya, José Ascención
AU - Domínguez-López, Mariana
AU - Kibanova, Daria
AU - Cervini-Silva, Javiera
N1 - Funding Information:
HC-G gratefully acknowledges the support of an undergraduate fellowship from DGAPA-UNAM. The authors thank Lic. María del Rocío Galindo Ortega (UAM-Cuajimalpa); M. in Sc. Claudia Rivera Cerecedo and Héctor Malagon Rivero (Bioterio, Instituto de Fisiología Celular, UNAM); M. Sc. Pilar Fernández Lomelin (Instituto de Geografia, UNAM) for technical assistance. This project was supported in part by Universidad Autónoma Metropolitana Unidad Cuajimalpa and ECACORE 2020 ( SEMARNAT CONACYT 23496 ).
PY - 2012/3
Y1 - 2012/3
N2 - Halloysite can serve as an alternative agent for drug delivery because its production is not tedious, hazardous, or expensive. In this study we show that halloysite presented anti-inflammatory properties comparable to indomethacin as evidenced by determination of the mieloperoxidase (MPO) enzymatic activity, a specific marker for migration and cellular infiltration. Edema reached maximum levels after 4h. Cellular migration was noted to be low. After 24h, however, cellular migration was noted to increase. Experiments conducted with mice primary peritoneal macrophages showed that halloysite (vs aminoguanidine) inhibited the production of nitric oxide. Halloysite inhibited oxidative stress via lipid peroxidation (ca. IC 50=2023ppm).
AB - Halloysite can serve as an alternative agent for drug delivery because its production is not tedious, hazardous, or expensive. In this study we show that halloysite presented anti-inflammatory properties comparable to indomethacin as evidenced by determination of the mieloperoxidase (MPO) enzymatic activity, a specific marker for migration and cellular infiltration. Edema reached maximum levels after 4h. Cellular migration was noted to be low. After 24h, however, cellular migration was noted to increase. Experiments conducted with mice primary peritoneal macrophages showed that halloysite (vs aminoguanidine) inhibited the production of nitric oxide. Halloysite inhibited oxidative stress via lipid peroxidation (ca. IC 50=2023ppm).
KW - Clays
KW - Indomethacin
KW - Inexpensive
KW - Naturally-occurring
KW - Vehicle-delivery drugs
UR - http://www.scopus.com/inward/record.url?scp=84857059722&partnerID=8YFLogxK
U2 - 10.1016/j.clay.2011.12.001
DO - 10.1016/j.clay.2011.12.001
M3 - Artículo
AN - SCOPUS:84857059722
SN - 0169-1317
VL - 57
SP - 10
EP - 16
JO - Applied Clay Science
JF - Applied Clay Science
ER -