TY - JOUR
T1 - Th2 cytokine response in Major Depressive Disorder patients before treatment
AU - Pavón, Lenin
AU - Sandoval-López, Gabriel
AU - Eugenia Hernández, María
AU - Loría, Frida
AU - Estrada, Iris
AU - Pérez, Mayra
AU - Moreno, Julia
AU - Ávila, Ulises
AU - Leff, Philippe
AU - Antón, Benito
AU - Heinze, Gerhard
N1 - Funding Information:
This research was supported by the Instituto Nacional de Psiquiatría “Ramón de la Fuente” Project No. 2078 and SALUD 2003-CONACYT-C01-14.
PY - 2006/3
Y1 - 2006/3
N2 - In Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired. We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group. The MDD subjects showed higher levels of cortisol and TNF-α, increased CD3+CD8+ and NK percentages, diminished B cell counts and no significant variations in CD3+CD4+ lymphocyte. Moreover, higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-γ (Th1) cytokines were also observed in the MDD group. Overall, we propose that all these changes could be related to the elevated cortisol levels seen in the MDD patients. Further studies are necessary to explore these findings and its implication in future therapeutic approach of MDD patients.
AB - In Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired. We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group. The MDD subjects showed higher levels of cortisol and TNF-α, increased CD3+CD8+ and NK percentages, diminished B cell counts and no significant variations in CD3+CD4+ lymphocyte. Moreover, higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-γ (Th1) cytokines were also observed in the MDD group. Overall, we propose that all these changes could be related to the elevated cortisol levels seen in the MDD patients. Further studies are necessary to explore these findings and its implication in future therapeutic approach of MDD patients.
KW - Cortisol
KW - Cytokines
KW - Major Depressive Disorder
KW - Psychoneuroimmunology
KW - Th2 immune response
UR - http://www.scopus.com/inward/record.url?scp=33244495502&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2005.08.014
DO - 10.1016/j.jneuroim.2005.08.014
M3 - Artículo
SN - 0165-5728
VL - 172
SP - 156
EP - 165
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -