TY - JOUR
T1 - Teratogenic effects of Plectranthus fruticosus essential oil in mice
AU - Pages, N.
AU - Fournier, G.
AU - Chamorro, G.
AU - Salazar, M.
PY - 1991/4
Y1 - 1991/4
N2 - The teratogenic potential of Plectranthus fruticosus essential oil was evaluated in Swiss‐OF1 mice injected subcutaneously. They received daily 0, 15, 45 or 135 mg/kg body weight on days 6 to 15 of gestation. A slight maternal toxicity, as evidenced by reduced weight gain and some physical alterations, was observed among treated groups compared with controls. Animals were killed and subjected to uterine examination on day 17 of pregnancy. Plectranthus fruticosus essential oil induced both embryo‐ and feto‐toxicity in the three treated groups, as manifested by a statistically significant increase in the numbers of resorbed and malformed fetuses. The observed malformations were predominantly related to the eyes (anophthalmia).
AB - The teratogenic potential of Plectranthus fruticosus essential oil was evaluated in Swiss‐OF1 mice injected subcutaneously. They received daily 0, 15, 45 or 135 mg/kg body weight on days 6 to 15 of gestation. A slight maternal toxicity, as evidenced by reduced weight gain and some physical alterations, was observed among treated groups compared with controls. Animals were killed and subjected to uterine examination on day 17 of pregnancy. Plectranthus fruticosus essential oil induced both embryo‐ and feto‐toxicity in the three treated groups, as manifested by a statistically significant increase in the numbers of resorbed and malformed fetuses. The observed malformations were predominantly related to the eyes (anophthalmia).
KW - Labiatae
KW - Plectranthus fruticosus
KW - anophthalmia
KW - essential oil
KW - teratogenicity
UR - http://www.scopus.com/inward/record.url?scp=0025972424&partnerID=8YFLogxK
U2 - 10.1002/ptr.2650050213
DO - 10.1002/ptr.2650050213
M3 - Artículo
SN - 0951-418X
VL - 5
SP - 94
EP - 96
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 2
ER -