TY - JOUR
T1 - Synthesis, spectral and QSAR studies of danazol-carbamazepine conjugate
AU - Lauro, Figueroa Valverde
AU - Francisco, Díaz Cedillo
AU - María, López Ramos
AU - Elodia, García Cervera
PY - 2011
Y1 - 2011
N2 - In this work, two danazol-carbamazepine conjugate was synthesized and characterized by spectroscopy and spectral analyses. In order to characterize the structural chemical requirements of danazol-carbamazepine conjugate, several parameters such as log P, π, Rm and Vm, Pc and St were evaluated. The results showed an increase in the values of log P for danazol-carbamazepine conjugate in comparison with danazol. The danazol-carbamazepine conjugate showed an increase in the values of π, R m and Vm, Pc and St with respect to danazol. In conclusion, all data suggest a relationship of the physicochemical descriptors evaluated with degree of lipophilicity from the danazolcarbamazepine conjugate.
AB - In this work, two danazol-carbamazepine conjugate was synthesized and characterized by spectroscopy and spectral analyses. In order to characterize the structural chemical requirements of danazol-carbamazepine conjugate, several parameters such as log P, π, Rm and Vm, Pc and St were evaluated. The results showed an increase in the values of log P for danazol-carbamazepine conjugate in comparison with danazol. The danazol-carbamazepine conjugate showed an increase in the values of π, R m and Vm, Pc and St with respect to danazol. In conclusion, all data suggest a relationship of the physicochemical descriptors evaluated with degree of lipophilicity from the danazolcarbamazepine conjugate.
KW - Danazol
KW - Lipophilicity
KW - QSAR
KW - Steric impediment
UR - http://www.scopus.com/inward/record.url?scp=79952175207&partnerID=8YFLogxK
M3 - Artículo
SN - 0970-7077
VL - 23
SP - 1669
EP - 1672
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 4
ER -