TY - JOUR
T1 - Synthesis of quinoxaline 1,4-di-n-oxide derivatives on solid support using room temperature and microwave-assisted solvent-free procedures
AU - Gómez-Caro, Lilia C.
AU - Sánchez-Sánchez, Mario
AU - Bocanegra-García, Virgilio
AU - Rivera, Gildardo
AU - Monge, Antonio
PY - 2011
Y1 - 2011
N2 - We describe the synthesis of 12 new ethyl and methyl quinoxaline-7- carboxylate 1,4-di-N-oxide derivatives on solid supports with room temperature and microwave-assisted solvent-free procedures. Results show that solid supports have good catalytic activity in the formation of quinoxaline 1,4-di-N-oxide derivatives. We found that florisil and montmorillonite KSF and K10 could be used as new, easily available, inexpensive alternatives of catalysts. Additionally, room temperature and microwave-irradiation solvent-free synthesis was more efficient than a conventional procedure (Beirut reaction), reducing reaction time and increasing yield.
AB - We describe the synthesis of 12 new ethyl and methyl quinoxaline-7- carboxylate 1,4-di-N-oxide derivatives on solid supports with room temperature and microwave-assisted solvent-free procedures. Results show that solid supports have good catalytic activity in the formation of quinoxaline 1,4-di-N-oxide derivatives. We found that florisil and montmorillonite KSF and K10 could be used as new, easily available, inexpensive alternatives of catalysts. Additionally, room temperature and microwave-irradiation solvent-free synthesis was more efficient than a conventional procedure (Beirut reaction), reducing reaction time and increasing yield.
KW - Quinoxaline
KW - Solid supports
KW - Solvent-free
UR - http://www.scopus.com/inward/record.url?scp=80053470477&partnerID=8YFLogxK
U2 - 10.1590/S0100-40422011000700008
DO - 10.1590/S0100-40422011000700008
M3 - Artículo
SN - 0100-4042
VL - 34
SP - 1147
EP - 1151
JO - Quimica Nova
JF - Quimica Nova
IS - 7
ER -