Synthesis of Novel Hybrid 4 H -Pyran-lipoic and 4 H -Pyran-azetidine Derivatives

Fernando Hernández-Borja; Leticia Contreras; Julio López; Yolanda Alcaraz; David Cruz; Samuel Estrada-Soto; Francisco Delgado; Miguel A. Vázquez

doi:10.1055/s-0036-1591730

Synthesis of Novel Hybrid 4 H -Pyran-lipoic and 4 H -Pyran-azetidine Derivatives

Fernando Hernández-Borja, Leticia Contreras, Julio López, Yolanda Alcaraz, David Cruz, Samuel Estrada-Soto, Francisco Delgado, Miguel A. Vázquez

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In this study, a molecular hybridization strategy was used to design and synthesize two novel series of hybrid compounds: 4 H -pyran-lipoic and 4 H -pyran-azetidine, employing ammonium hydroxide and involving the participation of aldehydes, malononitrile, and compounds derived from β-ketoesters to obtain the products with good yields.

Original language	English
Article number	ss-2017-m0506-op
Pages (from-to)	1020-1026
Number of pages	7
Journal	Synthesis (Germany)
Volume	50
Issue number	5
DOIs	https://doi.org/10.1055/s-0036-1591730
State	Published - 1 Mar 2018

Keywords

4 H -pyran-azetidine core
4 H -pyran-lipoic
molecular hybridization
multicomponent reaction

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10.1055/s-0036-1591730

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title = "Synthesis of Novel Hybrid 4 H -Pyran-lipoic and 4 H -Pyran-azetidine Derivatives",

abstract = "In this study, a molecular hybridization strategy was used to design and synthesize two novel series of hybrid compounds: 4 H -pyran-lipoic and 4 H -pyran-azetidine, employing ammonium hydroxide and involving the participation of aldehydes, malononitrile, and compounds derived from β-ketoesters to obtain the products with good yields.",

keywords = "4 H -pyran-azetidine core, 4 H -pyran-lipoic, molecular hybridization, multicomponent reaction",

author = "Fernando Hern{\'a}ndez-Borja and Leticia Contreras and Julio L{\'o}pez and Yolanda Alcaraz and David Cruz and Samuel Estrada-Soto and Francisco Delgado and V{\'a}zquez, {Miguel A.}",

note = "Publisher Copyright: {\textcopyright} 2018 Georg Thieme Verlag KG Stuttgart · New York.",

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doi = "10.1055/s-0036-1591730",

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TY - JOUR

T1 - Synthesis of Novel Hybrid 4 H -Pyran-lipoic and 4 H -Pyran-azetidine Derivatives

AU - Hernández-Borja, Fernando

AU - Contreras, Leticia

AU - López, Julio

AU - Alcaraz, Yolanda

AU - Cruz, David

AU - Estrada-Soto, Samuel

AU - Delgado, Francisco

AU - Vázquez, Miguel A.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - In this study, a molecular hybridization strategy was used to design and synthesize two novel series of hybrid compounds: 4 H -pyran-lipoic and 4 H -pyran-azetidine, employing ammonium hydroxide and involving the participation of aldehydes, malononitrile, and compounds derived from β-ketoesters to obtain the products with good yields.

AB - In this study, a molecular hybridization strategy was used to design and synthesize two novel series of hybrid compounds: 4 H -pyran-lipoic and 4 H -pyran-azetidine, employing ammonium hydroxide and involving the participation of aldehydes, malononitrile, and compounds derived from β-ketoesters to obtain the products with good yields.

KW - 4 H -pyran-azetidine core

KW - 4 H -pyran-lipoic

KW - molecular hybridization

KW - multicomponent reaction

UR - http://www.scopus.com/inward/record.url?scp=85034856142&partnerID=8YFLogxK

U2 - 10.1055/s-0036-1591730

DO - 10.1055/s-0036-1591730

M3 - Artículo

SN - 0039-7881

VL - 50

SP - 1020

EP - 1026

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 5

M1 - ss-2017-m0506-op

ER -

Synthesis of Novel Hybrid 4 H -Pyran-lipoic and 4 H -Pyran-azetidine Derivatives

Abstract

Keywords

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