Synthesis of novel β-functionalized α-oximinoketones via hetero-Michael addition of alcohols and mercaptans to enones

Pablo Bernal, Joaquín Tamariz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A new methodology has been developed for the preparation of β-alkoxy and β-sulfenyl ketones by hetero-Michael addition of the corresponding alcohols and thiols to enones under acidic and basic conditions. The direct conversion of enones into β-alkoxy and β-sulfenyl α- oximinoketones was also described.

Original languageEnglish
Pages (from-to)2905-2909
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number17
DOIs
StatePublished - 24 Apr 2006

Keywords

  • 2-Aryloxy-3-dimethylaminopropenoates
  • Benzofurans
  • Captodative olefins
  • Cyclization
  • Lewis acid catalysis

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