TY - JOUR
T1 - Synthesis of new aromatic phosphoramidates under a three-component reaction
AU - García-Aranda, Mónica I.
AU - Franco-Pérez, Marco
AU - Bonilla-Landa, Israel
AU - Castrejón-Flores, José Luis
AU - Zamudio-Medina, Angel
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - A fast, safe and accessible multicomponent reaction procedure is reported for the synthesis of symmetric and nonsymmetric benzyl-bisphosphoramidate derivatives. Our key reagents were 1,3-phenylenedimethanamine 3 conjointly with the five different phosphorous chlorides, O, O′-diethyl chlorothiophosphate 1, diphenyl phosphoryl chloride 2, diethyl chlorophosphate 5, N, N, N ′, N′-tetramethylphosphorodiamidic chloride 7 and O, O′-dimethyl chlorothiophosphate 9. A total of seven products were obtained, five of them none reported before. As far as we know, our work constitutes the first approach for the synthesis of nonsymmetric benzyl-bisphosphoramidate derivatives. The presence of our adducts were always confirmed by NMR spectroscopy (1H, 13C and 31P) and mass spectrometry.
AB - A fast, safe and accessible multicomponent reaction procedure is reported for the synthesis of symmetric and nonsymmetric benzyl-bisphosphoramidate derivatives. Our key reagents were 1,3-phenylenedimethanamine 3 conjointly with the five different phosphorous chlorides, O, O′-diethyl chlorothiophosphate 1, diphenyl phosphoryl chloride 2, diethyl chlorophosphate 5, N, N, N ′, N′-tetramethylphosphorodiamidic chloride 7 and O, O′-dimethyl chlorothiophosphate 9. A total of seven products were obtained, five of them none reported before. As far as we know, our work constitutes the first approach for the synthesis of nonsymmetric benzyl-bisphosphoramidate derivatives. The presence of our adducts were always confirmed by NMR spectroscopy (1H, 13C and 31P) and mass spectrometry.
KW - Three-component reaction
KW - addition-elimination reaction
KW - benzyl bisphosphoramidate
KW - phosphorous chlorides
KW - symmetric and nonsymmetric derivatives
UR - http://www.scopus.com/inward/record.url?scp=85128210369&partnerID=8YFLogxK
U2 - 10.1080/10426507.2022.2053854
DO - 10.1080/10426507.2022.2053854
M3 - Artículo
AN - SCOPUS:85128210369
SN - 1042-6507
VL - 197
SP - 885
EP - 890
JO - Phosphorus, Sulfur and Silicon and the Related Elements
JF - Phosphorus, Sulfur and Silicon and the Related Elements
IS - 9
ER -