TY - JOUR
T1 - Synthesis of hybrid compounds apatite-alendronate by reactive milling and effects on the structure and morphology of the apatite phase
AU - Vargas-Becerril, Nancy
AU - Patiño-Carachure, Cristobal
AU - Rodriguez-Lorenzo, Luis M.
AU - Téllez-Jurado, Lucía
N1 - Funding Information:
The authors thank the financial support from CONACyT, the National Politecnic Institute IPN, Mexico City , and the Science and Technology Institute of Polymers ITCP, Madrid Spain , for their support and for providing the necessary tools to do this work through CICYT project MAT2010-18155 .
PY - 2013/5
Y1 - 2013/5
N2 - The preparation of apatite-alendronate hybrid materials by reactive milling is proposed in this work. Calcium phosphate compounds of various compositions have been associated to bisphosphonates and found suitable for local application with release kinetics of the drug compatible with the inhibition of bone resorption. Hybrid compounds have been obtained by reactive milling. The compositions used were: AP(X-100), Alendronate(X) where X=7 and X=15. An interaction between the hydroxyl group of the apatite and the amine group of alendronate can be identified with FTIR and enables to confirm the formation of the hybrids. The incorporation of the alendronate hinders the growing of the apatite crystals resulting in smaller coherent domains of diffraction for the apatite phase.
AB - The preparation of apatite-alendronate hybrid materials by reactive milling is proposed in this work. Calcium phosphate compounds of various compositions have been associated to bisphosphonates and found suitable for local application with release kinetics of the drug compatible with the inhibition of bone resorption. Hybrid compounds have been obtained by reactive milling. The compositions used were: AP(X-100), Alendronate(X) where X=7 and X=15. An interaction between the hydroxyl group of the apatite and the amine group of alendronate can be identified with FTIR and enables to confirm the formation of the hybrids. The incorporation of the alendronate hinders the growing of the apatite crystals resulting in smaller coherent domains of diffraction for the apatite phase.
KW - Alendronate
KW - D. Apatite
KW - Hybrids
KW - Reactive milling
UR - http://www.scopus.com/inward/record.url?scp=84874645496&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2012.10.239
DO - 10.1016/j.ceramint.2012.10.239
M3 - Artículo
SN - 0272-8842
VL - 39
SP - 3921
EP - 3929
JO - Ceramics International
JF - Ceramics International
IS - 4
ER -