TY - JOUR
T1 - Synthesis of 5-aryl-1,4-benzodiazepine derivatives attached in resorcinaren-PAMAM dendrimers and their anti-cancer activity
AU - Cortez-Maya, Sandra
AU - Hernández-Ortega, Simón
AU - Ramírez-Apan, Teresa
AU - Lijanova, Irina V.
AU - Martínez-García, Marcos
N1 - Funding Information:
This work was supported by DGAPA-UNAM (IN202010-3) grant. We would also like to thank O. H. Rios, L. Velasco, S. E. Huerta, M. M. R. Patiño, M. A. Peña Gonzalez for technical assistance.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - A series of resorcinaren-PAMAM dendrimers with benzodiazepines in the periphery were synthesized and their anticancer properties studied. The synthesized dendrimers showed potential anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4-benzodiazepine. The dendrimers were characterized by IR, 1H and 13C NMR, UV-vis absorption, electrospray (ES) and/or MALDI-TOF mass spectrometries.
AB - A series of resorcinaren-PAMAM dendrimers with benzodiazepines in the periphery were synthesized and their anticancer properties studied. The synthesized dendrimers showed potential anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4-benzodiazepine. The dendrimers were characterized by IR, 1H and 13C NMR, UV-vis absorption, electrospray (ES) and/or MALDI-TOF mass spectrometries.
KW - Anticancer activity
KW - Benzodiazepines
KW - Dendrimers
KW - PAMAM
KW - Resorcinarenes
UR - http://www.scopus.com/inward/record.url?scp=84855194558&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2011.10.070
DO - 10.1016/j.bmc.2011.10.070
M3 - Artículo
SN - 0968-0896
VL - 20
SP - 415
EP - 421
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 1
ER -