TY - JOUR
T1 - Synthesis of 3-alkylideneisoindolinones and isoindolones by a Horner-Wadsworth-Emmons reaction
AU - Reyes-González, Miguel Ángel
AU - Zamudio-Medina, Ángel
AU - Ramírez-Marroquín, Oscar Abelardo
AU - Ordóñez, Mario
N1 - Funding Information:
The authors thank CONACYT of Mexico for financial support via project 181816. We thank V. Labastida-Galván for the determination of mass spectra. MARG and OARM also thank the CONACYT for Graduate Scholarships.
PY - 2014/6
Y1 - 2014/6
N2 - A series of 3-alkylideneisoindolinones was prepared by a Horner-Wadsworth-Emmons (HWE) reaction of aromatic aldehydes with N-(ω-hydroxyalkyl)-substituted 3-phosphoisoindolin-1-ones, obtained in one-pot synthesis from 2-formylbenzoic acid. Additionally, the intramolecular HWE reaction of the N-(ω-formylalkyl)-substituted phosphoisoindolin-1-ones afforded the corresponding isoindolone derivatives. Graphical Abstract: [Figure not available: see fulltext.]
AB - A series of 3-alkylideneisoindolinones was prepared by a Horner-Wadsworth-Emmons (HWE) reaction of aromatic aldehydes with N-(ω-hydroxyalkyl)-substituted 3-phosphoisoindolin-1-ones, obtained in one-pot synthesis from 2-formylbenzoic acid. Additionally, the intramolecular HWE reaction of the N-(ω-formylalkyl)-substituted phosphoisoindolin-1-ones afforded the corresponding isoindolone derivatives. Graphical Abstract: [Figure not available: see fulltext.]
KW - Heterocycles
KW - Phosphonates
KW - Three-component reaction
KW - Wittig reaction
UR - http://www.scopus.com/inward/record.url?scp=84901014895&partnerID=8YFLogxK
U2 - 10.1007/s00706-013-1146-9
DO - 10.1007/s00706-013-1146-9
M3 - Artículo
AN - SCOPUS:84901014895
SN - 0026-9247
VL - 145
SP - 1001
EP - 1007
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 6
ER -