Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases

Alcives Avila-Sorrosa, Alejandro Y. Bando-Vázquez, Verónica Alvarez-Alvarez, Erick Suarez-Contreras, Rocío Nieto-Meneses, Benjamín Nogueda-Torres, María Elena Vargas-Díaz, Francisco Díaz-Cedillo, Reyna Reyes-Martínez, Simon Hernandez-Ortega, David Morales-Morales

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3 Scopus citations

Abstract

A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).

Original languageEnglish
Article number128520
JournalJournal of Molecular Structure
Volume1218
DOIs
StatePublished - 15 Oct 2020

Keywords

  • Chagas disease
  • Crystal structures
  • Fluorinated schiff bases
  • Neglected diseases
  • Non-covalent molecular interactions
  • Trypanocidal activity

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