Synthesis and in vitro evaluation of tetrahydroquinoline derivatives as antiproliferative compounds of breast cancer via targeting the GPER

Medicine & Life Sciences

• 1,2,3,4-tetrahydroquinoline 100%
• G-Protein-Coupled Receptors 53%
• Estrogen Receptors 49%
• Computer Simulation 40%
• Breast Neoplasms 34%
• In Vitro Techniques 23%
• (Z)2-(5-(4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid 23%
• Ligands 22%
• Cell Line 18%
• Cell Proliferation 14%
• Molecular Dynamics Simulation 11%
• MCF-7 Cells 11%
• Inhibitory Concentration 50 9%
• Binding Sites 8%
• Growth 5%
• Therapeutics 3%

Chemistry

• Estrogen 57%
• Antiproliferative 53%
• Polar Effect 14%
• Ligand 13%
• Acetyl Group 12%
• Calorific Value 11%
• Gibbs Free Energy 8%
• Molecular Dynamics 7%
• Simulation 6%
• Molecule 3%